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首页> 外文期刊>Journal of vascular surgery >Normal serum concentrations of S-100 protein and changes in cerebrospinal fluid concentrations of S-100 protein during and after thoracoabdominal aortic aneurysm surgery: Is S-100 protein a biochemical marker of clinical value in detecting spinal cor
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Normal serum concentrations of S-100 protein and changes in cerebrospinal fluid concentrations of S-100 protein during and after thoracoabdominal aortic aneurysm surgery: Is S-100 protein a biochemical marker of clinical value in detecting spinal cor

机译：胸腹主动脉瘤手术期间和之后正常的血清S-100蛋白质浓度和脑脊液中S-100蛋白质浓度的变化：S-100蛋白质是否是检测脊髓水肿临床价值的生化指标

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PURPOSE: This study was performed to determine the concentration of S-100 protein in serum and in the cerebrospinal fluid (CSF) during and 24 hours after thoracoabdominal aortic aneurysm repair. METHODS: This prospective study was performed at St. Antonius Hospital in Nieuwegein, The Netherlands. Eight patients who underwent elective thoracoabdominal aortic surgery participated in the study. Arterial blood and CSF samples for analysis of S-100 protein were drawn after induction of anesthesia, during the cross-clamp period of the critical segment, after 5 minutes of reperfusion, during the closure of the skin, and 24 hours after closure of the skin. RESULTS: No increase in S-100 protein concentration could be detected in serum (< 0.2 microg/L). The S-100 protein concentration in CSF increased during the procedure in all patients (4.2 +/- 3.1 microg/L). However, in one patient, who became paraplegic, the S-100 protein concentration in CSF increased even further after 24 hours (10 microg/L). CONCLUSIONS: The preliminary results suggest that S-100 protein in CSF may be a marker of clinical value in evaluating the effects of measures to detect and reduce spinal cord ischemia.
机译：目的：进行这项研究以确定胸腹主动脉瘤修复期间和术后24小时血清和脑脊液（CSF）中S-100蛋白的浓度。方法：这项前瞻性研究在荷兰Nieuwegein的St. Antonius医院进行。接受选择性胸腹主动脉手术的八名患者参加了该研究。在麻醉诱导后，关键节段的交叉钳位期间，再灌注5分钟后，皮肤闭合期间以及闭合后24小时，抽取动脉血和CSF样品以分析S-100蛋白。皮肤。结果：血清（<0.2 microg / L）中未检测到S-100蛋白浓度增加。在该过程中，所有患者的脑脊液中S-100蛋白浓度均升高（4.2 +/- 3.1 microg / L）。但是，在一名截瘫的患者中，脑脊液中S-100蛋白的浓度在24小时后甚至进一步升高（10微克/升）。结论：初步结果表明，脑脊液中S-100蛋白可能是评估检测和减轻脊髓缺血措施的效果的临床价值标志。

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