...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>JPEN. Journal of parenteral and enteral nutrition. >Early postoperative enteral nutrition improves peripheral protein kinetics in upper gastrointestinal cancer patients undergoing complete resection: a randomized trial.
【24h】

Early postoperative enteral nutrition improves peripheral protein kinetics in upper gastrointestinal cancer patients undergoing complete resection: a randomized trial.

机译：术后早期肠内营养改善了接受完全切除的上消化道癌患者外周蛋白的动力学：一项随机试验。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Patients with upper gastrointestinal (GI) tract malignancies are at risk for malnutrition and postoperative morbidity and mortality. We examined the protein kinetic effects of early enteral feeding in this population and compared it with results in patients receiving IV fluid. METHODS: Twenty-nine patients undergoing resection of an upper GI tract malignancy were prospectively randomized to either enteral feeding starting on postoperative day (POD) 1 via a jejunostomy tube (FEED, n = 12) or IV fluid (IVF, n = 17). On POD5, all patients underwent a protein metabolic study using [3H]phenylalanine to determine forearm skeletal muscle (nmol phenylalanine/100 g/min) protein net balance. Free fatty acids (FFA, mEq/dL) and insulin levels (mU/mL) were measured. RESULTS: Protein net balance was significantly less negative in the FEED group compared with the IVF group (-1.4 +/- 0.8 vs -5.0 +/- 1.4, p < .05). Respiratory quotient was significantly increased in patients receiving enteral feeding (0.85 +/- 0.02 vs 0.78 +/- 0.02 FEED vs IVF, p < .05). FFA levels were significantly decreased in the FEED group (0.36 +/- 0.04 vs 0.85 +/- 0.07, p < .05). Insulin levels were significantly elevated in the FEED group (19.8 +/- 4.5 vs 9.3 +/- 0.8, p < .05). Insulin levels correlated with amino acid fluxes. CONCLUSIONS: Postoperative enteral nutrition in upper GI cancer patients results in an improvement in protein kinetic net balance and amino acid flux across peripheral tissue. In addition, insulin levels are elevated, and this elevation correlates with amino fluxes across the forearm. By improving peripheral protein kinetics, early postoperative enteral nutrition may potentially contribute to a decrease in postoperative morbidity and mortality in upper gastrointestinal cancer patients.
机译：背景：上消化道（GI）恶性肿瘤患者有营养不良和术后发病和死亡的风险。我们检查了该人群早期肠内喂养对蛋白质动力学的影响，并将其与接受静脉输液的患者的结果进行了比较。方法：将29例行上消化道恶性肿瘤切除的患者从术后第1天（POD）开始通过空肠造口管（FEED，n = 12）或静脉输液（IVF，n = 17）进行肠内喂养。在POD5上，所有患者均进行了蛋白质代谢研究，使用[3H]苯丙氨酸确定前臂骨骼肌（nmol苯丙氨酸/ 100 g / min）的蛋白质净平衡。测量游离脂肪酸（FFA，mEq / dL）和胰岛素水平（mU / mL）。结果：与IVF组相比，FEED组的蛋白质净平衡显着降低（-1.4 +/- 0.8对-5.0 +/- 1.4，p <.05）。接受肠内喂养的患者的呼吸商显着增加（0.85 +/- 0.02 vs 0.78 +/- 0.02 FEED vs IVF，p <.05）。 FEED组的FFA水平显着降低（0.36 +/- 0.04对0.85 +/- 0.07，p <.05）。 FEED组的胰岛素水平显着升高（19.8 +/- 4.5 vs 9.3 +/- 0.8，p <.05）。胰岛素水平与氨基酸通量相关。结论：上消化道癌患者的术后肠内营养可改善周围周围组织的蛋白质动力学净平衡和氨基酸通量。另外，胰岛素水平升高，并且该升高与跨前臂的氨基通量相关。通过改善外周蛋白动力学，术后早期肠内营养可能有助于降低上消化道癌患者的术后发病率和死亡率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号