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首页> 外文期刊>Journal of Zhejiang University Science: An international applied physics & engineering journal >Investigating the role of ~(99m)Tc-TRODAT-1 SPECT imaging in idiopathic Parkinson's disease
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Investigating the role of ~(99m)Tc-TRODAT-1 SPECT imaging in idiopathic Parkinson's disease

机译：研究〜（99m）Tc-TRODAT-1 SPECT成像在特发性帕金森病中的作用

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Objective: To investigate the role of ~(99m)Tc-TRODAT-l SPECT in diagnosis and assessing severity of idiopathic Parkinson's disease (PD). Methods: Thirty-eight patients with primary, tentative diagnosis of PD and eighteen age-matched normal controls were studied with ~(99m)Tc-TRODAT-l SPECT imaging. The regions of interests (ROIs) were drawn manually on cerebellum (CB), occipital cortex (OC) and three transverse plane slice-views of striatums, the semiquantitative BG (back-ground)/[(OC+CB)/2] were then calculated. Results: A lower uptake of ~(99m)Tc-TRODAT-l in striatums were displayed in thirty-six out of thirty-eight PD patients by visual inspection, compared to controls. In twenty-four PD cases with HYS (Hoehn and Yahr scale) stage I, a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affected limbs than in the same regions of the controls, although the striatal uptake was bilaterally reduced. Using Spearman correlation analysis showed that the reduction of the uptake ratios significantly con-elated with the UPDRS in striatum and all its subregions in the PD group (P< 0.05), a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P<0.05). However, analysis of variance (ANOVA) did not show any relationship between the decreasing uptake of ~(99m)Tc-TRODAT-1 and increasing severity of PD patients, although the specific uptake of ~(99m)Tc-TRODAT-l was continuously decreased in the striatum by visual inspection with the progress of PD from HYS stage I to III. Conclusion: ~(99m)Tc-TRODAT-l SPECT imaging may serve as a useful method for improving the correct diagnosis of PD. In assessing the role of ~(99m)Tc-TRODAT-l SPECT in disease severity of PD, UPDRS can offer a comprehensive index, although the Hoehn and Yahr assessment may be available in part.
机译：目的：探讨〜（99m）Tc-TRODAT-1 SPECT在诊断和评估特发性帕金森病（PD）的严重性中的作用。方法：对〜（99m）Tc-TRODAT-1 SPECT显像对38例初步诊断为PD的患者和18例年龄相匹配的正常对照组进行了研究。在小脑（CB），枕叶皮质（OC）和纹状体的三个横切面视图上手动绘制感兴趣区域（ROIs），半定量BG（背景）/ [（OC + CB）/ 2]为然后计算。结果：与对照组相比，通过目视检查，在38例PD患者中，有36例显示纹状体中〜（99m）Tc-TRODAT-1的摄取较低。在HYS（Hoehn和Yahr量表）I期的24例PD患者中，纹状体及其患侧对侧纹状体次区域的DAT摄取损失比对照组的相同区域更大，尽管纹状体摄取双边减少。使用Spearman相关分析显示，PD组纹状体及其所有子区域中摄取率的降低与UPDRS显着相关（P <0.05），通过使用Hoehn和Yahr（P <0.05）。但是，方差分析（ANOVA）并未显示〜（99m）Tc-TRODAT-1的摄取减少与PD患者严重程度增加之间有任何关系，尽管〜（99m）Tc-TRODAT-1的特异性摄取是连续的通过目视检查，随着PD从HYS阶段I进展到III，纹状体减少。结论：〜（99m）Tc-TRODAT-1 SPECT成像可能是改善PD正确诊断的有用方法。在评估〜（99m）Tc-TRODAT-1 SPECT在PD疾病严重程度中的作用时，尽管Hoehn和Yahr评估可能部分可用，但UPDRS可以提供​​综合指标。

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