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首页> 外文期刊>Journal of women’s health >Correlates of cervicovaginal human papillomavirus detection in perimenopausal women.
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Correlates of cervicovaginal human papillomavirus detection in perimenopausal women.

机译：围绝经期妇女宫颈阴道人乳头瘤病毒检测的相关性。

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OBJECTIVE: The aim of this research was to determine correlates of prevalent cervicovaginal human papillomavirus (HPV) infection in perimenopausal women. METHODS: A total of 178 women, ages 40-60, were recruited from four clinics in the metropolitan area of Baltimore, Maryland. A self-collected cervicovaginal specimen and questionnaire were completed following enrollment and consent. HPV was detected by L1 consensus polymerase chain reaction (PCR) and genotyped using a prototype line blot assay. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CIs) from Poisson regression models with robust variance identified correlates of prevalent HPV infection. RESULTS: Prevalence of any HPV genotype at baseline among 172 women with complete data was 20% (6% for high-risk HPV). HPV prevalence was higher among single compared to married women (aPR = 4.3 [95% CI: 2.0, 9.5]), and among women with >or=2 sex partners in the last six months compared to women who reported none (aPR = 4.9 [1.7, 13.9]) after adjustment for confounders. Menopausal stage was also associated with HPV detection, with increased prevalence among perimenopausal compared to premenopausal women (aPR 2.3 [1.1, 5.1]), after adjustment for confounders. Age was moderately correlated with menopausal staging (r = 0.57). CONCLUSIONS: Our observations suggest the independent associations of sexual behavior and hormones on prevalent HPV in perimenopausal women. Age was not a good surrogate for menopausal stage, as it was only moderately correlated with menopausal stage.
机译：目的：本研究的目的是确定围绝经期妇女中普遍存在的宫颈阴道人乳头瘤病毒（HPV）感染的相关性。方法：从马里兰州巴尔的摩市区的四家诊所招募了178名年龄在40至60岁之间的妇女。在入组并征得同意后，完成了自我收集的宫颈阴道标本和调查表。通过L1共有聚合酶链反应（PCR）检测HPV，并使用原型线印迹法进行基因分型。来自Poisson回归模型的经过调整的患病率（aPR）和95％置信区间（CIs）具有强大的方差，可确定流行的HPV感染的相关性。结果：172名具有完整数据的女性在基线时的任何HPV基因型患病率为20％（高危HPV为6％）。与已婚女性相比，单身女性的HPV患病率更高（aPR = 4.3 [95％CI：2.0，9.5]），并且在过去六个月中与性伴侣>或= 2的女性相较没有报告的女性（aPR = 4.9） [1.7，13.9]）。调整混杂因素后，绝经期也与HPV检测相关，与绝经前妇女相比，围绝经期患病率增加（aPR 2.3 [1.1，5.1]）。年龄与绝经分期有中等相关性（r = 0.57）。结论：我们的观察结果表明，性行为和激素与绝经后女性流行的HPV有独立的联系。年龄不是绝经期的好替代品，因为它与绝经期只有中等程度的相关性。

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