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首页> 外文期刊>Journal of women’s health >A randomized controlled trial of prenatal physical activity to prevent gestational diabetes: design and methods.
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A randomized controlled trial of prenatal physical activity to prevent gestational diabetes: design and methods.

机译：预防妊娠糖尿病的产前身体活动的随机对照试验：设计和方法。

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BACKGROUND: Women diagnosed with gestational diabetes mellitus (GDM) are at substantially increased risk of developing type 2 diabetes and obesity, currently at epidemic rates in the United States. GDM, therefore, identifies a population of women at high risk of developing type 2 diabetes and provides an opportunity to intervene before the development of this disorder. It is well recognized that acute as well as chronic physical activity improves glucose tolerance in type 2 diabetes. To date, however, primary prevention trials have not been conducted to test whether an increase in physical activity reduces risk of developing GDM among women at high risk of this disorder. METHODS: The aims of this study are to investigate the effects of a motivationally targeted, individually tailored 12-week physical activity intervention on (1) development of GDM, (2) serum biomarkers associated with insulin resistance, and (3) the adoption and maintenance of exercise during pregnancy. Women at high risk of GDM are recruited in early pregnancy and randomized to either an individually tailored exercise intervention or a comparison health and wellness intervention. RESULTS: The overall goal of the exercise intervention is to encourage pregnant women to achieve the American College of Obstetricians and Gynecologists guidelines for physical activity during pregnancy through increasing walking and developing a more active lifestyle. CONCLUSIONS: The intervention takes into account the specific social, cultural, economic, and physical environmental challenges faced by pregnant women of diverse socioeconomic and ethnic backgrounds.
机译：背景：目前在美国，被诊断患有妊娠糖尿病（GDM）的妇女患2型糖尿病和肥胖症的风险大大增加。因此，GDM可以识别出罹患2型糖尿病的高风险女性人群，并提供了在这种疾病发生之前进行干预的机会。众所周知，急性和慢性体育活动都能改善2型糖尿病的葡萄糖耐量。然而，迄今为止，尚未进行初级预防试验来测试体育锻炼的增加是否能降低罹患这种疾病的高风险女性中发生GDM的风险。方法：本研究的目的是研究动机针对性的，量身定制的为期12周的体育锻炼干预对（1）GDM的发展，（2）与胰岛素抵抗相关的血清生物标志物以及（3）采用和治疗的影响。在怀孕期间保持运动。患有GDM的高风险女性在怀孕初期被招募，并随机分为个体定制的运动干预措施或比较健康与保健干预措施。结果：运动干预的总体目标是鼓励孕妇通过增加步行和发展更积极的生活方式来达到美国妇产科学院孕妇在怀孕期间进行体育锻炼的准则。结论：干预措施考虑了具有不同社会经济和种族背景的孕妇所面临的特定的社会，文化，经济和自然环境挑战。

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