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首页> 外文期刊>Journal of women’s health >Challenging and complex decisions in the management of the BRCA mutation carrier
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Challenging and complex decisions in the management of the BRCA mutation carrier

机译：BRCA突变携带者管理中具有挑战性和复杂的决策

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摘要

Women afflicted by the hereditary breast and ovarian cancer syndrome face complex decisions regarding medical interventions aimed at reducing their risk of ovarian and breast cancer, interventions which in turn may interfere with their fertility and cause early menopause. This review addresses selected topics of importance and controversy in the management of the BRCA mutation carrier, such as psychological well-being and quality of life, breast and ovarian cancer screening, risk-reducing interventions for breast cancer and ovarian cancer, the issue of hysterectomy at the time of the risk-reducing salpingo-oophorectomy, health consequences of early surgical menopause, and safety of hormonal therapy after oophorectomy. The information presented is based on an extensive review of the literature on the selected topics and on the expertise of our multidisciplinary team.
机译：受遗传性乳腺癌和卵巢癌综合症折磨的妇女面临着旨在降低其卵巢癌和乳腺癌风险的医学干预措施的复杂决策，而这些干预措施又可能会干扰其生育能力并导致更年期提前。这篇综述探讨了在BRCA突变携带者管理中的重要主题和争议，例如心理健康和生活质量，乳腺癌和卵巢癌筛查，降低乳腺癌和卵巢癌风险的干预措施，子宫切除术的问题降低输卵管输卵管卵巢切除术时的风险，更年期早期外科手术对健康的影响以及输卵管切除术后激素治疗的安全性。所提供的信息基于对所选主题的文献的广泛审查以及我们多学科团队的专业知识。

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