Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascular risk factors, such as lipid profiles and glucose, in women with a history of hypertensive pregnancy disorders. Homocysteine is a sensitive indicator of increased risk but data on homocysteine levels in women with a history of hypertensive pregnancy disorders are inconsistent. Design: This cohort study included 279 women with a history of hypertensive pregnancy disorders at term and 85 women with a history of uncomplicated pregnancies who participated in the Hypitat Risk Assessment Study (HyRAS). Methods: Blood samples for total homocysteine determination were taken 2.5 years postpartum. Homocysteine levels were determined in plasma using an immunoassay. Results: Women with a history of hypertensive pregnancy disorders had significant higher median homocysteine levels (10.66mol/L) 2.5 years postpartum compared with women with a history uncomplicated pregnancies (9.82mol/L; p=0.002). Women with a history of hypertensive pregnancy disorders had a higher risk of having a homocysteine level in the highest quartile (odds ratio 3.4, 95% confidence interval 1.5-7.6). Conclusion: At 2.5 years postpartum, women with a history hypertensive pregnancy disorders had higher homocysteine levels than women who had uncomplicated pregnancies. Although higher homocysteine levels might be a potential link between a history of hypertensive pregnancy disorders and increased cardiovascular disease risk later in life, the clinical implications remain an area for future research.
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机译：背景：许多长期随访研究的结果表明，妊娠高血压疾病与生命后期罹患心血管疾病的风险增加有关。最近，在患有高血压妊娠疾病史的女性中，心血管疾病危险因素（如脂质分布和葡萄糖）升高的发现已证实了这种推测的关系。同型半胱氨酸是增加风险的敏感指标，但有妊娠高血压病史的女性中同型半胱氨酸水平的数据不一致。设计：这项队列研究包括参加Hypitat风险评估研究（HyRAS）的279名足月有高血压妊娠病史的妇女和85名有单纯妊娠史的妇女。方法：产后2.5年采集血样进行总同型半胱氨酸测定。使用免疫测定法测定血浆中的同型半胱氨酸水平。结果：有妊娠高血压病史的妇女在产后2.5年的同型半胱氨酸中位数水平（10.66mol / L）明显高于没有妊娠史的妇女（9.82mol / L; p = 0.002）。有高血压妊娠史的妇女在最高四分位数中具有高半胱氨酸水平的风险较高（优势比3.4，95％置信区间1.5-7.6）。结论：在产后2.5年，有妊娠高血压病史的妇女的同型半胱氨酸水平高于没有单纯妊娠的妇女。尽管较高的同型半胱氨酸水平可能是高血压妊娠疾病史和以后生命中心血管疾病风险增加之间的潜在联系，但其临床意义仍是未来研究的领域。
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