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首页> 外文期刊>Journal of women’s health >Association of physical activity level and stroke outcomes in men and women: a meta-analysis.
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Association of physical activity level and stroke outcomes in men and women: a meta-analysis.

机译：男性和女性身体活动水平与中风结果的关联：一项荟萃分析。

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OBJECTIVE: The protective effect of physical activity (PA) on risk of stroke remains controversial as a result of lack of insight into the sources of heterogeneity between studies. We performed a comprehensive meta-analysis of studies to (1) quantify the association between PA level and risk of stroke outcomes and (2) test the hypothesis that the association of PA level with stroke outcomes will be similar between men and women. The outcome measures are stroke incidence, stroke mortality, or both. METHODS: Cohort studies were identified by searching MEDLINE and EMBASE (from 1986 to 2005) and meta-analysis conducted according to meta-analysis of Observational Studies in Epidemiology (MOOSE) group recommendations. Data were reported as pooled relative risk (RR) and 95% confidence intervals (CI) using random-effects models to assess the association of stroke outcomes with PA level. Heterogeneity was investigated, and sensitivity analysis was performed. Stratified analysis by gender was performed. RESULTS: Of 992 articles, 13 satisfied all eligibility criteria and were studied. Compared with low PA, moderate PA caused an 11% reduction in risk of stroke outcome (RR = 0.89, 95% CI 0.86-0.93, p < 0.01) and high PA a 19% reduction (RR = 0.81, CI 0.77-0.84, p < 0.01). Among the men, results showed a 12% reduction in risk associated with moderate PA (RR = 0.88, CI 0.82-0.94, p < 0.01) and 19% reduction for high PA (RR = 0.81, CI 0.75-0.87, p < 0.01). Among the women, results showed a 24% reduction in risk for high PA (RR = 0.76, CI 0.64-.89, p < 0.01). There was, however, no significant risk reduction associated with a moderate PA level in women. CONCLUSIONS: Increased PA level appears beneficial in reduction of risk of stroke and related outcomes. However, higher levels of PA may be required in women to achieve as significant a risk reduction as in men. An exercise regimen tailored to women to improve related physiological mechanisms will likely be beneficial.
机译：目的：由于缺乏对研究之间异质性来源的了解，体育锻炼（PA）对中风风险的保护作用仍存在争议。我们对研究进行了全面的荟萃分析，以（1）量化PA水平与中风预后风险之间的关联，以及（2）检验以下假设：男女PA水平与中风预后之间的关联相似。结果指标是中风发生率，中风死亡率或两者。方法：通过搜索MEDLINE和EMBASE（从1986年至2005年）和根据流行病学观察性研究（MOOSE）组推荐的荟萃分析进行的荟萃分析，确定队列研究。使用随机效应模型评估卒中预后与PA水平的相关性，将数据报告为合并的相对风险（RR）和95％置信区间（CI）。研究了异质性，并进行了敏感性分析。按性别进行分层分析。结果：在992篇文章中，有13篇符合所有资格标准并进行了研究。与低PA相比，中度PA可使中风结局风险降低11％（RR = 0.89，95％CI 0.86-0.93，p <0.01），而高PA可降低19％（RR = 0.81，CI 0.77-0.84， p <0.01）。在男性中，结果显示，中度PA的风险降低12％（RR = 0.88，CI 0.82-0.94，p <0.01），高PA的风险降低19％（RR = 0.81，CI 0.75-0.87，p <0.01） ）。在女性中，结果显示高PA风险降低24％（RR = 0.76，CI 0.64-.89，p <0.01）。但是，女性中度PA水平并没有显着降低风险。结论：增加PA水平似乎有利于降低中风风险和相关结果。但是，女性可能需要更高水平的PA才能达到与男性同样显着的风险降低。为女性量身定制的运动方案，以改善相关的生理机制可能是有益的。

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