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首页> 外文期刊>Diabetes, obesity & metabolism >Strong family history predicts a younger age of onset for subjects diagnosed with type 2 diabetes.
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Strong family history predicts a younger age of onset for subjects diagnosed with type 2 diabetes.

机译：强大的家族史预测诊断为2型糖尿病的受试者的发病年龄较年轻。

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Aims: Age of onset of type 2 diabetes is becoming earlier and with it there is an increase in the development of chronic complications. This study examined the relationship between the strength of family history of diabetes on (i) age of diabetes onset and (ii) prevalence of diabetic complications. Research design and methods: Data on family history of diabetes and age of diabetes onset were prospectively collected on 5193 subjects. Family members were deemed to include grandparents, parents, siblings, aunts/uncles and children. To adjust for family size and to assess effects of pathway to diagnosis, we also contacted a subset of 180 patients selected on the basis of the strength of family histories of diabetes. A full assessment for diabetic complications including retinopathy, neuropathy and renal and macrovascular status was performed for the total cohort. Results: The more cases of diabetes found in a family, the younger the age of onset of type 2 diabetes. This phenomenon does not appear to be dueto patients with strong family history of diabetes being more concerned about the possibility of having diabetes. The effect of strong family history is also evident in many ethnic groups when examined individually, although they differ from each other in their characteristic age of onset of diabetes. Once adjusted for duration of diabetes, strength of family history does not appear to affect metabolic profiles or prevalence of chronic complications. Conclusions: There is a strong relationship between the number of affected family members with diabetes and age of developing diabetes. The genetic and environmental factors underlying this phenomenon remain to be elucidated. However, it may be one of the reasons explaining why type 2 diabetes is affecting younger people worldwide.
机译：目的：2型糖尿病的发病年龄变得更早，并且随之而来的是慢性并发症的发展。这项研究检查了糖尿病家族史的强度与（i）糖尿病发病年龄和（ii）糖尿病并发症患病率之间的关系。研究设计和方法：前瞻性收集了5193名受试者的糖尿病家族史和糖尿病发病年龄的数据。家庭成员被认为包括祖父母，父母，兄弟姐妹，阿姨/叔叔和孩子。为了调整家庭规模并评估诊断途径的影响，我们还联系了根据糖尿病家族史的强度选择的180例患者。整个队列对糖尿病并发症进行了全面评估，包括视网膜病变，神经病变以及肾脏和大血管状态。结果：家庭中患糖尿病的病例越多，2型糖尿病的发病年龄就越小。这种现象似乎不是由于家族有糖尿病家族史的患者更担心患有糖尿病的可能性所致。单独检查时，尽管许多家族在糖尿病发作的特征年龄上互不相同，但在许多族裔中都有很强的家族史的影响也很明显。一旦对糖尿病的持续时间进行了调整，家族史的强度似乎就不会影响代谢谱或慢性并发症的患病率。结论：患糖尿病的家庭成员人数与发展中的糖尿病年龄之间有很强的关系。造成这种现象的遗传和环境因素仍有待阐明。但是，这可能是解释2型糖尿病为何影响全世界年轻人的原因之一。

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