Treatment intensification with an insulin degludec (IDeg)/insulin aspart (IAsp) co-formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized, controlled phase III trial

Rodbard H. W.; Cariou B.; Pieber T. R.; Endahl L. A.; Zacho J.; Cooper J. G.

首页> 外文期刊>Diabetes, obesity & metabolism >Treatment intensification with an insulin degludec (IDeg)/insulin aspart (IAsp) co-formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized, controlled phase III trial

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Treatment intensification with an insulin degludec (IDeg)/insulin aspart (IAsp) co-formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized, controlled phase III trial

机译：与基础IDeg和餐后IAsp相比，在2型糖尿病中，每天两次使用地高胰岛素（IDeg）/门冬胰岛素（IAsp）共制剂进行的治疗强化：一项随机，对照的III期试验

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Aims: To evaluate the efficacy and safety of two insulin intensification strategies for patients with type 2 diabetes previously treated with basal insulin - insulin degludec (IDeg) and insulin aspart (IAsp) - administered as a co-formulation (IDegAsp) or as a basal-bolus regimen (IDeg and IAsp in separate injections).

机译：目的：评估两种胰岛素强化策略对既往接受基础胰岛素治疗的2型糖尿病患者-地高地松（IDeg）和门冬胰岛素（IAsp）-以联合制剂（IDegAsp）或基础给药的有效性和安全性推注方案（IDeg和IAsp分别注射）。

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《Diabetes, obesity & metabolism》 |2016年第3期|共7页
作者
Rodbard H. W.; Cariou B.; Pieber T. R.; Endahl L. A.; Zacho J.; Cooper J. G.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
efficacy; insulin aspart; insulin degludec; insulin intensification; type 2 diabetes;

机译：疗效;门冬胰岛素;地德胰岛素;胰岛素强化;2型糖尿病;

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1. Treatment intensification with an insulin degludec (IDeg)/insulin aspart (IAsp) co-formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized, controlled phase III trial [J] . Rodbard H. W., Cariou B., Pieber T. R., Diabetes, obesity & metabolism . 2016,第3期

机译：与基础IDeg和餐后IAsp相比，在2型糖尿病中，每天两次使用地高胰岛素（IDeg）/门冬胰岛素（IAsp）共制剂进行的治疗强化：一项随机，对照的III期试验
2. Superior glycaemic control with once-daily insulin degludec/insulin aspart versus insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: A randomized, controlled phase 3 trial [J] . OnishiY., OnoY., Rab?lR., Diabetes, obesity & metabolism . 2013,第9期

机译：在口服药物控制不充分的日本2型糖尿病成年人中，每天一次使用地格胰岛素/天冬氨酸胰岛素与甘精胰岛素相比，可实现更好的血糖控制：一项随机，对照的3期临床研究
3. Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial [J] . Tinahones F. J., Gross J. L., Onaca A., Diabetes, obesity & metabolism . 2014,第10期

机译：需要胰岛素强化的2型糖尿病患者，每天两次使用lispro低剂量胰岛素与基础甘精胰岛素每日一次，餐前lispro胰岛素每日一次：一项随机IV期试验
4. Comparing artificial pancreas controlled by hybrid "closed-loop" machine learning (ML) trained algorithm to multi-daily injection (MDI), insulin pump without CGM and "sensor assisted" insulin pump therapies for Diabetes Type 1 (DT1) treatment [C] . Joan Carles Peiró International Conference on Data Analytics for Business and Industry: Way Towards a Sustainable Economy . 2020

机译：将通过混合“闭环”机器学习（ML）控制的人工胰腺培训算法对多日注于多日注射（MDI），胰岛素泵而没有CGM和“传感器辅助”胰岛素泵疗法1型（DT1）处理
5. A 4-month randomized controlled clinical trial of adjuvant Exenatide or Pramlintide versus insulin alone in pediatric type 1 diabetes mellitus: Effect on glycemic control. [D] . Withycombe, Sarah Elizabeth. 2010

机译：儿科1型糖尿病患者中艾塞那肽或普兰林肽与单独使用胰岛素的4个月随机对照临床试验：对血糖控制的影响。
6. Treatment intensification with an insulin degludec (IDeg)/insulin aspart (IAsp) co‐formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized controlled phase III trial [O] . H. W. Rodbard, B. Cariou, T. R. Pieber, -1

机译：与基础IDeg和餐后IAsp相比在2型糖尿病中每天两次使用地高胰岛素（IDeg）/门冬胰岛素（IAsp）共配制的强化治疗：一项随机对照的III期试验
7. Treatment intensification with an insulin degludec ( IDeg )/insulin aspart ( IAsp ) co‐formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized, controlled phase III trial [O] . H. W. Rodbard, B. Cariou, T. R. Pieber, 2016

机译：用胰岛素Degludec（IDEG）/胰岛素Aspart（IASP）共同配制的治疗与2型糖尿病（2型糖尿病）相比两次共配制：随机，受控期IIAI试验

Treatment intensification with an insulin degludec (IDeg)/insulin aspart (IAsp) co-formulation twice daily compared with basal IDeg and prandial IAsp in type 2 diabetes: a randomized, controlled phase III trial

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