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首页> 外文期刊>Diabetes/metabolism research and reviews >Long-term high density lipoprotein infusion ameliorates metabolic phenotypes of diabetic db/db mice
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Long-term high density lipoprotein infusion ameliorates metabolic phenotypes of diabetic db/db mice

机译：长期高密度脂蛋白输注可改善糖尿病db / db小鼠的代谢表型

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摘要

Background: Lower quantity and quality of high density lipoprotein (HDL) are important characteristics of type 2 diabetes mellitus. Acute HDL infusion results in a greater fall of plasma glucose in diabetes patients. Here, we aim to investigate the influence of long-term HDL infusion on metabolic phenotypes of diabetic db/db mice. Methods: High density lipoprotein was introduced to db/db mice twice a week for 4weeks. The phenotypes of the mice were monitored by analyzing metabolic parameters. Glycogen analysis was performed with amyloglucosidase. The corresponding signaling molecules were detected by western blot. Results: Long-term introduction of HDL decreased plasma glucose levels of db/db mice. Glycogen deposition was enhanced in gastrocnemius muscle, paralleling the elevated glycogen synthase kinase-3 phosphorylation. Meanwhile, increased Akt-Ser473 and adenosine monophosphate-activated protein kinase phosphorylations were detected in the muscle. Moreover, HDL reduced blood glucose and free fatty acids and improved pancreatic islet structure and function with increased C-peptide. Furthermore, decreased interleukin-6, C-reactive protein, monocyte chemoattractant protein-1, resistin, and malondialdehyde, as well as enhanced leptin levels were detected in HDL-treated mice. Conclusion: Results of the present study suggest that long-term HDL infusion has positive therapeutic effects on the metabolic disturbances of db/db diabetic mice.
机译：背景：高密度脂蛋白（HDL）的数量和质量较低是2型糖尿病的重要特征。急性HDL输注导致糖尿病患者的血浆葡萄糖下降更大。在这里，我们旨在调查长期输注高密度脂蛋白对糖尿病db / db小鼠代谢表型的影响。方法：每周两次将高密度脂蛋白引入db / db小鼠，持续4周。通过分析代谢参数监测小鼠的表型。用淀粉葡糖苷酶进行糖原分析。通过蛋白质印迹检测相应的信号分子。结果：长期引入HDL可降低db / db小鼠的血浆葡萄糖水平。糖原沉积在腓肠肌中得到增强，与糖原合酶激酶-3磷酸化的升高平行。同时，在肌肉中检测到增加的Akt-Ser473和腺苷单磷酸激活的蛋白激酶磷酸化。此外，HDL可降低血糖和游离脂肪酸，并通过增加C肽改善胰岛的结构和功能。此外，在HDL处理的小鼠中检测到白介素6，C反应蛋白，单核细胞趋化蛋白1，抵抗素和丙二醛降低，瘦素水平升高。结论：本研究结果表明，长期输注HDL对db / db糖尿病小鼠的代谢紊乱具有积极的治疗作用。

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