...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diabetes/metabolism research and reviews >Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
【24h】

Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.

机译：调节白色脂肪组织中褐色样脂肪细胞形成的分子途径。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adipose tissue is functionally composed of brown adipose tissue and white adipose tissue. The unique thermogenic capacity of brown adipose tissue results from expression of uncoupling protein 1 in the mitochondrial inner membrane. On the basis of recent findings that adult humans have functionally active brown adipose tissue, it is now recognized as playing a much more important role in human metabolism than was previously thought. More importantly, brown-like adipocytes can be recruited in white adipose tissue upon environmental stimulation and pharmacologic treatment, and this change is associated with increased energy expenditure, contributing to a lean and healthy phenotype. Thus, the promotion of brown-like adipocyte development in white adipose tissue offers novel possibilities for the development of therapeutic strategies to combat obesity and related metabolic diseases. In this review, we summarize recent advances in understanding the molecular mechanisms involved in the recruitment of brown-like adipocyte in white adipose tissue.
机译：脂肪组织在功能上由棕色脂肪组织和白色脂肪组织组成。棕色脂肪组织独特的产热能力来自线粒体内膜中解偶联蛋白1的表达。根据最近的发现，即成年人具有功能活跃的棕色脂肪组织，现在人们认为它在人类新陈代谢中起着比以前认为的重要得多的作用。更重要的是，在环境刺激和药物治疗后，褐色脂肪细胞可以募集到白色脂肪组织中，这种变化与能量消耗增加有关，有助于形成瘦弱和健康的表型。因此，促进白色脂肪组织中褐色样脂肪细胞的发育为对抗肥胖症和相关代谢疾病的治疗策略的发展提供了新的可能性。在这篇综述中，我们总结了了解在白色脂肪组织中募集棕色样脂肪细胞的分子机制的最新进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号