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首页> 外文期刊>Journal of medical primatology >Relationship of creatine kinase, aspartate aminotransferase, lactate dehydrogenase, and proteinuria to cardiomyopathy in the owl monkey (Aotus vociferans)
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Relationship of creatine kinase, aspartate aminotransferase, lactate dehydrogenase, and proteinuria to cardiomyopathy in the owl monkey (Aotus vociferans)

机译：猫头鹰猴（Aotus vociferans）肌酸激酶，天冬氨酸转氨酶，乳酸脱氢酶和蛋白尿与心肌病的关系

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Background The purpose of this study was to determine serum reference values for creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in captive-born and wild-caught owl monkeys to assess their usefulness for diagnosing myocardial disease. Methods Blood samples were collected for CK, AST and LDH determinations. In addition, urine samples were collected and semiquantitative tests performed. Results There was no statistically significant difference between CK, AST and LDH when comparing both groups. However, when comparing monkeys with proteinuria to those without proteinuria, a statistically significant difference in CK value was observed (P = 0.021). In addition the CK/AST ratio revealed that 29% of the animals included in this study had values suggesting cardiac infarction. Grossly, cardiac concentric hypertrophy of the left ventricle and small, pitted kidneys were the most common findings. Microscopically, myocardial fibrosis, contraction band necrosis, hypertrophy and hyperplasia of coronary arteries, medium-sized renal arteries and afferent glomerular arteriolae were the most significant lesions, along with increased mesangial matrix and hypercellularity of glomeruli, Bowman's capsule and peritubular space fibroplasia. Conclusions These findings suggest that CK, AST and LDH along with urinalysis provide a reliable method for diagnosing cardiomyopathies in the owl monkey. In addition, CK/AST ratio, proteinuria and the observed histological and ultrastructural changes suggest that Aotus vociferans suffer from arterial hypertension and chronic myocardial infarction.
机译：背景技术这项研究的目的是确定圈养出生和野生的猫头鹰猴中肌酸激酶（CK），天冬氨酸转氨酶（AST）和乳酸脱氢酶（LDH）的血清参考值，以评估其在诊断心肌疾病中的有用性。方法采集血样进行CK，AST和LDH测定。另外，收集尿液样本并进行半定量测试。结果比较两组时，CK，AST和LDH之间无统计学差异。但是，将具有蛋白尿的猴子与没有蛋白尿的猴子进行比较时，观察到CK值具有统计学上的显着差异（P = 0.021）。此外，CK / AST比值显示该研究中29％的动物具有提示心脏梗塞的值。总的来说，最常见的发现是左心室心脏同心肥大和肾脏小，凹陷。在显微镜下，心肌纤维化，收缩带坏死，冠状动脉肥大和增生，中型肾动脉和传入肾小球小动脉是最显着的病变，肾小球的肾小球系膜基质和细胞增高，鲍曼氏囊和肾小管周围纤维化。结论这些发现表明CK，AST和LDH以及尿液分析为诊断猫头鹰猴的心肌病提供了一种可靠的方法。此外，CK / AST比，蛋白尿以及观察到的组织学和超微结构变化表明，声母菜患有动脉高血压和慢性心肌梗塞。

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