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首页> 外文期刊>Journal of medical primatology >The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers
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The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers

机译：恒河猴（Macaca mulatta）中口服氯胺酮和氯胺酮/美托咪定与肌内氯胺酮相比的疗效以及给药途径对血液学应激指标的影响

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Background This study compared the efficacy of two orally-dosed (PO) anaesthetic regimens for chemical immobilization in rhesus macaques (Macaca mulatta), versus the standard protocol of intramuscular (TM) ketamine. In addition, the effects of dosing route on haematological stress markers were evaluated. Methods Testing was conducted on 18 chronically housed animals. Animals were trained to accept oral dosing and then randomly assigned to one of three drug regimens: (1) ketamine IM, (2) ketamine PO, (3) Ketamine/medetomidine PO. Sedation levels for each regimen were evaluated. Results Oral dosing alone was not sufficient to achieve a plane of sedation that allowed for safe handling. Serum cortisol and glucose levels were unchanged across groups, although differences were observed in the leukogram profiles. Conclusion The oral dosages used in this study fell short in providing adequate sedation for safe handling for routine veterinary procedures. Leukogram profiles indicated that orally dosed animals experienced a higher level of stress.
机译：背景本研究比较了两种口服（PO）麻醉方案在恒河猴（Macaca mulatta）中化学固定的效果，与肌肉注射（TM）氯胺酮的标准方案进行比较。此外，评估了给药途径对血液学应激标志物的影响。方法对18只长期饲养的动物进行了测试。训练动物接受口服给药，然后将其随机分配至以下三种药物治疗方案之一：（1）氯胺酮IM，（2）氯胺酮PO，（3）氯胺酮/美托咪定PO。评估每种方案的镇静水平。结果单独口服给药不足以达到可以安全处理的镇静效果。两组间的血清皮质醇和葡萄糖水平没有变化，尽管在白细胞分布图上观察到差异。结论本研究中使用的口服剂量不足以为常规兽医程序安全处理提供足够的镇静作用。白血球分布图表明口服给药的动物承受较高的压力。

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