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首页> 外文期刊>Journal of orofacial pain. >Chronic temporomandibular disorders are not necessarily associated with a compromised endogenous analgesic system.
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Chronic temporomandibular disorders are not necessarily associated with a compromised endogenous analgesic system.

机译：慢性颞下颌疾病不一定与内源性镇痛系统受损有关。

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摘要

Aims: To test whether temporomandibular disorders (TMD) case-control differences in conditioned pain modulation (CPM) exist, using a mechanically evoked temporal summation (TS) model. Methods: A series of 10 repetitive, mildly noxious, mechanical stimuli were applied to the fingers of 30 women with TMD, who had a primary diagnosis of masticatory myofascial pain, and 30 age-matched healthy women. The subjects rated the pain intensity caused by the 1st, 5th, and 10th stimuli in the series. To evaluate CPM, the same series of mechanical stimulations were applied with concomitant exposure of the other hand to a painfully cold water bath. Statistical inferences were based on t tests, chi-square tests, or analysis of variance (ANOVA), as appropriate. Results: Pain ratings increased significantly with stimulus repetition (P < .01) and CPM significantly reduced TS of pain (P < .01). Of particular note, both groups showed very similar degrees of CPM, with no significant group difference. Conclusion: Painful TMD is not necessarily associated with a compromised ability to engage the endogenous analgesic system in an experimental setting.
机译：目的：使用机械诱发的时间总和（TS）模型来测试条件性疼痛调节（CPM）中是否存在颞下颌疾病（TMD）病例对照差异。方法：对30例初步诊断为咀嚼肌筋膜疼痛的TMD妇女和30例年龄相匹配的健康妇女进行一系列的10次重复，轻度伤害性机械刺激。受试者对系列中的第1次，第5次和第10次刺激引起的疼痛强度进行了评分。为了评估CPM，在另一只手同时暴露于痛苦的冷水浴中的同时，施加了相同系列的机械刺激。统计推论基于t检验，卡方检验或适当的方差分析（ANOVA）。结果：通过重复刺激，疼痛等级显着提高（P <.01），而CPM显着降低了疼痛的TS（P <.01）。特别值得注意的是，两组的CPM程度非常相似，两组之间无显着差异。结论：痛苦的TMD不一定与在实验环境中使用内源性止痛系统的能力受损有关。

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