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首页> 外文期刊>Journal of orofacial pain. >Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain.
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Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain.

机译：在小鼠中的等效线描影法分析加巴喷丁和去甲替林在缓解口面部疼痛中的相互作用。

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Aims: To evaluate the nature of the antinociceptive interaction of systemic administration of a combination of the anticonvulsant gabapentin with the antidepressant nortriptyline, by isobolographic analysis in the formalin orofacial pain test of mice. Methods: The study was carried out in 168 male CF-1 mice weighing 30 g, and the protocol was to test each drug (at dosages of 1, 3, 10, 30, and 100 mg/kg of gabapentin and 0.1, 1, 3, 10, and 30 mg/kg of nortriptyline; ip) alone and in combination. The isobolographic assay has two phases: phase 1 corresponds to the 5-minute period starting immediately after the formalin injection and reflects a tonic acute pain due to peripheral nociceptor sensitization; phase 2 is recorded as the 10-minute period starting 20 minutes after the formalin injection and reflects an inflammatory pain state. Results were analyzed by Student t test for independent means. Results: Gabapentin was 1.61 times more potent in phase 2 than in phase 1, and nortriptyline 1.37 times more potent in phase 2 than in phase 1. The combination of both drugs was synergic, with an index of interaction of 0.134 and 0.148 for phase 1 and phase 2, respectively. Differences in the pharmacological profiles of gabapentin and nortriptyline could underlie the synergism of the two drugs. Conclusion: The findings of this study are important, because they are concordant with some clinical studies and also raise the possibility of potential clinical advantages of combining gabapentin and nortriptyline in pain management, since the low doses of the components may potentially have a lower incidence of adverse reactions.
机译：目的：通过在福尔马林口腔颌面疼痛试验中进行等效线描记分析，评估抗惊厥药加巴喷丁与抗抑郁药去甲替林的组合全身给药的抗伤害感受相互作用的性质。方法：本研究是在168只体重为30 g的雄性CF-1小鼠中进行的，实验方案为测试每种药物（加巴喷丁的剂量分别为1、3、10、30和100 mg / kg，0.1、1， 3、10和30 mg / kg的去甲替林（ip）单独或组合使用。等效线描记法测定法分为两个阶段：阶段1对应于福尔马林注射后立即开始的5分钟时间，反映了由于周围伤害感受器致敏引起的强直性急性疼痛。阶段2记录为福尔马林注射后20分钟开始的10分钟，反映出炎症性疼痛状态。通过学生t检验分析结果的独立性。结果：加巴喷丁在第2阶段的效力是第1阶段的1.61倍，去甲替林在第2阶段的效力是第1阶段的1.37倍。两种药物的组合具有协同作用，第1阶段的相互作用指数分别为0.134和0.148。和阶段2。加巴喷丁和去甲替林的药理学差异可能是两种药物协同作用的基础。结论：这项研究的发现很重要，因为它们与一些临床研究相一致，并且还增加了加巴喷丁和去甲替林联合用于疼痛治疗的潜在临床优势的可能性，因为低剂量的该组分可能会降低其发生率。不良反应。

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