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首页> 外文期刊>Journal of orofacial pain. >Persistent Neuropathic Pain Influences Persistence Behavior in Rats
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Persistent Neuropathic Pain Influences Persistence Behavior in Rats

机译：持续性神经性疼痛影响大鼠的持续行为

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Aims: To determine whether self-regulation can be studied successfully in a rodent model and whether persistent facial pain influences self-regulatory behavior. Methods: Thirty male Sprague-Dawley rats, divided into two groups, (1) chronic constriction injury of the infraorbital nerve (CCI-ION) and (2) naive, were used in a two-part behavioral paradigm of self-regulation. This paradigm consisted of both a cued goo-go task (part one) and a persistence trial (part two). All animals were acclimated and trained for a period of 4 weeks priorto the experimental manipulation and then tested for a total of 5 weeks following experimental manipulation. Results were analyzed with t tests, one-way analysis of variance, and two-way, repeated measures analysis of variance. Results: CCI-ION surgery induced significant mechanical hypersensitivity of the ipsilateral whisker pad that began 3 weeks postsurgery and persisted through the duration of the experiment (P < .001).
机译：目的：确定是否可以在啮齿动物模型中成功研究自我调节，以及持续的面部疼痛是否影响自我调节行为。方法：将30只雄性Sprague-Dawley大鼠分为两组，（1）眶下神经慢性压迫性损伤（CCI-ION）和（2）天真，用于两部分的行为自我调节行为模式。此范例包括提示执行/不执行任务（第一部分）和持久性试用（第二部分）。在实验操作之前，使所有动物适应和训练4周，然后在实验操作之后测试总共5周。结果通过t检验，单向方差分析和双向重复性方差分析进行分析。结果：CCI-ION手术引起同侧晶须垫明显的机械性超敏反应，该现象从术后3周开始，一直持续到实验期间（P <.001）。

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