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首页> 外文期刊>Journal of cellular biochemistry. >MiR-199b-5p targets HER2 in breast cancer cells
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MiR-199b-5p targets HER2 in breast cancer cells

机译：MiR-199b-5p靶向乳腺癌细胞中的HER2

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摘要

HER2 (ErbB2) has been reported to be overexpressed in 20-30% of breast cancer and confers poor survival because of high proliferation and metastasis rates. MicroRNAs are small noncoding RNAs that are responsible for the post-transcriptional regulation of target genes. We found miR-199b-5p inhibited HER2 expression by direct targeting its 3′-untranslated region (3′UTR) in breast cancer cells. In addition, miR-199b-5p inhibited HER2 downstream signaling by ERK1/2 and AKT pathways in breast cancer cells. Besides, transwell migration, wound healing, and clonogenicity were obviously inhibited by overexpression of miR-199b-5p in HER2-positive breast cancer cells. We also found that miR-199b-5p could enhance the suppression of trastuzumab on cell migration and clonogenicity. These results suggest that miR-199b-5p may have the potential to be a novel important alternative therapeutic target for HER2-positive breast cancer.
机译：据报道，HER2（ErbB2）在20％至30％的乳腺癌中过表达，并且由于高增殖和转移率而赋予较差的生存率。 MicroRNA是小的非编码RNA，负责靶基因的转录后调控。我们发现miR-199b-5p通过直接靶向乳腺癌细胞中的3'-非翻译区（3'UTR）来抑制HER2表达。另外，miR-199b-5p通过乳腺癌细胞中的ERK1 / 2和AKT途径抑制HER2下游信号传导。此外，miR-199b-5p在HER2阳性乳腺癌细胞中的过表达明显抑制了跨孔迁移，伤口愈合和克隆形成性。我们还发现miR-199b-5p可以增强曲妥珠单抗对细胞迁移和克隆形成的抑制作用。这些结果表明，miR-199b-5p可能成为HER2阳性乳腺癌的新型重要替代治疗靶标。

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