...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular biochemistry. >Hydrogen peroxide as a damage signal in tissue injury and inflammation: Murderer, mediator, or messenger?
【24h】

Hydrogen peroxide as a damage signal in tissue injury and inflammation: Murderer, mediator, or messenger?

机译：过氧化氢作为组织损伤和炎症中的损伤信号：凶手，介体或信使？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tissue injury and inflammation are associated with increased production of reactive oxygen species (ROS), which have the ability to induce oxidative injury to various biomolecules resulting in protein dysfunction, genetic instability, or cell death. However, recent observations indicate that formation of hydrogen peroxide (H2O2) during tissue injury is also an essential feature of the ensuing wound healing response, and functions as an early damage signal to control several critical aspects of the wound healing process. Because innate oxidative wound responses must be tightly coordinated to avoid chronic inflammation or tissue injury, a more complete understanding is needed regarding the origins and dynamics of ROS production, and their critical biological targets. This prospect highlights the current experimental evidence implicating H2O2 in early epithelial wound responses, and summarizes technical advances and approaches that may help distinguish its beneficial actions from its more deleterious actions in conditions of chronic tissue injury or inflammation. J. Cell. Biochem. 115: 427-435, 2014.
机译：组织损伤和炎症与活性氧（ROS）产生增加有关，活性氧具有诱导各种生物分子氧化损伤的能力，从而导致蛋白质功能障碍，遗传不稳定或细胞死亡。但是，最近的观察表明，组织损伤期间过氧化氢（H2O2）的形成也是随后的伤口愈合反应的重要特征，并作为早期损伤信号来控制伤口愈合过程的几个关键方面。由于必须紧密协调先天的氧化性伤口反应，以避免慢性炎症或组织损伤，因此需要对ROS产生的起源和动态及其关键的生物学靶点有更全面的了解。该前景突出了目前涉及过氧化氢参与早期上皮伤口反应的实验证据，并总结了技术进步和方法，这些技术和方法可能有助于在慢性组织损伤或炎症的情况下将其有益作用与更有害的作用区分开。 J.细胞。生化。 115：427-435，2014年。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号