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首页> 外文期刊>Journal of cellular biochemistry. >Efficacy of tumor-targeting Salmonella Typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer
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Efficacy of tumor-targeting Salmonella Typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer

机译：靶向鼠伤寒沙门氏菌A1-R对转移性和弥漫性人卵巢癌裸鼠模型的功效

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摘要

We report here the efficacy of tumor-targeting Salmonella typhimurium A1-R (A1-R) on mouse models of disseminated and metastatic ovarian cancer. The proliferation-inhibitory efficacy of A1-R on human ovarian cancer cell lines (SKOV-3-GFP, OVCAR-3-RFP) was initially demonstrated in vitro. Orthotopic and dissemination mouse models of ovarian cancer were made with the human ovarian cancer cell line SKOV-3-GFP. After tumor implantation, the mice were treated with A1-R (5 × 107 colony-forming units [CFU], i.v.), and there were no severe adverse events observed. In the orthotopic model, tumor volume after treatment was 276 ± 60.8mm3, compared to 930 ± 342mm3 in the untreated control group (P = 0.022). There was also a significant difference in survival between treated mice and untreated mice in a peritoneal dissemination model (P = 0.005). The results of this report demonstrate that A1-R is effective for highly aggressive human ovarian cancer in metastatic and dissemination mouse models and suggest its clinical potential for this highly treatment-resistant disease.
机译：我们在这里报告靶向肿瘤的鼠伤寒沙门氏菌A1-R（A1-R）在弥散性和转移性卵巢癌的小鼠模型上的功效。最初在体外证明了A1-R对人卵巢癌细胞系（SKOV-3-GFP，OVCAR-3-RFP）的增殖抑制作用。用人卵巢癌细胞系SKOV-3-GFP建立了卵巢癌的原位和扩散小鼠模型。肿瘤植入后，用A1-R（5×107集落形成单位[CFU]，静脉内）治疗小鼠，没有观察到严重的不良事件。在原位模型中，治疗后的肿瘤体积为276±60.8mm3，而未经治疗的对照组为930±342mm3（P = 0.022）。在腹膜扩散模型中，治疗小鼠和未治疗小鼠的存活率也存在显着差异（P = 0.005）。该报告的结果表明，A1-R在转移和扩散小鼠模型中对高度侵袭性的人卵巢癌有效，并暗示了其对这种高度治疗耐药性疾病的临床潜力。

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