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首页> 外文期刊>Journal of cellular biochemistry. >Raf kinase inhibitory protein role in the molecular subtyping of breast cancer
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Raf kinase inhibitory protein role in the molecular subtyping of breast cancer

机译：Raf激酶抑制蛋白在乳腺癌分子亚型中的作用

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In this study, we examined the association between the RKIP expression and the molecular subtypes of breast cancer. Microarray gene expression data of 2,333 human breast cancer from 26 different cohorts performed on Affymetrix U133A or U133Plus2 platforms were downloaded from Array Express and Gene Expression Omnibus and the molecular subtype of breast cancer for the samples was determined by single sample Gene Set Enrichment Analysis. Differences in recurrence-free survival (RFS) were tested using the Log-rank test in univariate analysis and displayed using Kaplan-Meier curves. Cox proportional-hazards model was used to calculate the hazard ratio using univariate and multivariate analysis. Loss or reduced RKIP expression was associated with reduced RFS in breast cancer using univariate and multivariate analyses, which was independent of lymph node (LN) metastasis status. Basal-like, Claudin-low, and Her-2-enriched tumors had significantly lower RKIP levels compared to other subclasses (P < 0.0001). Conversely, the Luminal subclass exhibited the highest expression levels of RKIP (P < 0.0001 for Luminal A and P = 0.0005 for Luminal B subtype), while in normal-like breast cancer subtype, RKIP expression was not informative. RKIP expression was prognostic in ER+ and ER- subgroups. RKIP expression had no significant prognostic power within Basal-like, Claudine-low, Luminal B, or Her-2-enriched breast cancer subtypes. However, its expression pinpointed excellent from intermediate-poor Luminal A survivors, in both ER+ (P = 0.035) and ER- (P = 0.012) subgroups, especially in LN negative breast cancers. In conclusion, RKIP expression adds significant value to the molecular subclassification of breast cancer especially for the Luminal A subtype. J. Cell. Biochem. 115: 488-497, 2014.
机译：在这项研究中，我们检查了RKIP表达与乳腺癌分子亚型之间的关联。从Array Express和Gene Expression Omnibus下载了在Affymetrix U133A或U133Plus2平台上进行的来自26个不同队列的2,333个人类乳腺癌的微阵列基因表达数据，并通过单样本基因集富集分析确定了样本的乳腺癌分子亚型。使用单变量分析中的对数秩检验测试无复发生存期（RFS）的差异，并使用Kaplan-Meier曲线显示。使用Cox比例风险模型通过单变量和多变量分析来计算风险比。使用单因素和多因素分析，乳腺癌中RFS的降低或与RKIP表达的降低有关，而RFS的降低与淋巴结转移状态无关。与其他亚类相比，基底样，克劳丁低和Her-2富集的肿瘤的RKIP水平显着降低（P <0.0001）。相反，Luminal亚类表现出最高的RKIP表达水平（Luminal A亚型的P <0.0001，Luminal B亚型的P = 0.0005），而在正常乳腺癌亚型中，RKIP的表达不足。 RKIP表达在ER +和ER-亚组中是预后的。 RKIP表达在基底样，Claudine-low，Luminal B或富含Her-2的乳腺癌亚型中没有明显的预后能力。但是，它的表达在ER +（P = 0.035）和ER-（P = 0.012）亚组中，特别是在LN阴性乳腺癌中，从中等贫乏的Luminal A幸存者中精确定位。总之，RKIP表达为乳腺癌的分子亚分类增加了重要价值，特别是对于Luminal A亚型。 J.细胞。生化。 115：488-497，2014年。

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