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Tissue crosstalk in lung development

机译：肺发育中的组织串扰

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Lung development follows a stereotypic program orchestrated by key interactions among epithelial and mesenchymal tissues. Deviations from this developmental program can lead to pulmonary diseases including bronchopulmonary dysplasia and pulmonary hypertension. Significant efforts have been made to examine the cellular and molecular basis of the tissue interactions underlying these stereotypic developmental processes. Genetically engineered mouse models, lung organ culture, and advanced imaging techniques are a few of the tools that have expanded our understanding of the tissue interactions that drive lung development. Intimate crosstalk has been identified between the epithelium and mesenchyme, distinct mesenchymal tissues, and individual epithelial cells types. For interactions such as the epithelial-mesenchymal crosstalk regulating lung specification and branching morphogenesis, the key molecular players, FGF, BMP, WNT, and SHH, are well established. Additionally, VEGF regulation underlies the epithelial-endothelial crosstalk that coordinates airway branching with angiogenesis. Recent work also discovered a novel role for SHH in the epithelial-to-mesenchymal (EMT) transition of the mesothelium. In contrast, the molecular basis for the crosstalk between upper airway cartilage and smooth muscle is not yet known. In this review we examine current evidence of the tissue interactions and molecular crosstalk that underlie the stereotypic patterning of the developing lung and mediate injury repair. J. Cell. Biochem. 115: 1469-1477, 2014.
机译：肺发育遵循由上皮组织和间质组织之间的关键相互作用所安排的定型程序。偏离这一发展计划可能导致肺部疾病，包括支气管肺发育不良和肺动脉高压。已经做出了巨大的努力来检查这些定型发展过程背后的组织相互作用的细胞和分子基础。基因工程小鼠模型，肺脏器官培养和先进的成像技术是一些工具，这些工具扩展了我们对驱动肺部发育的组织相互作用的理解。在上皮和间充质，不同的间充质组织和单个上皮细胞类型之间已发现密切的串扰。对于相互作用，例如调节肺规格和分支形态发生的上皮-间充质相互作用，已经很好地建立了关键分子参与者，即FGF，BMP，WNT和SHH。另外，VEGF调节是上皮-内皮串扰的基础，该串扰协调气道分支与血管生成。最近的工作还发现了SHH在间皮上皮到间充质（EMT）过渡中的新作用。相反，尚不清楚上呼吸道软骨与平滑肌之间串扰的分子基础。在这篇综述中，我们研究了组织相互作用和分子串扰的最新证据，这些证据是发展中肺部定型模式的基础，并介导了损伤修复。 J.细胞。生化。 115：1469-1477，2014。

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