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首页> 外文期刊>Journal of cellular biochemistry. >Methyl-CpG-Binding Protein (MBD) Family: Epigenomic Read-Outs Functions and Roles in Tumorigenesis and Psychiatric Diseases
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Methyl-CpG-Binding Protein (MBD) Family: Epigenomic Read-Outs Functions and Roles in Tumorigenesis and Psychiatric Diseases

机译：甲基CpG结合蛋白（MBD）家族：表观基因组读出功能及其在肿瘤发生和精神疾病中的作用

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摘要

Epigenetics is the study of the heritable changes on gene expression that are responsible for the regulation of development and that have an impact on several diseases. However, it is of equal importance to understand how epigenetic machinery works. DNA methylation is the most studied epigenetic mark and is generally associated with the regulation of gene expression through the repression of promoter activity and by affecting genome stability. Therefore, the ability of the cell to interpret correct methylation marks and/or the correct interpretation of methylation plays a role in many diseases. The major family of proteins that bind methylated DNA is the methyl-CpG binding domain proteins, or the MBDs. Here, we discuss the structure that makes these proteins a family, the main functions and interactions of all protein family members and their role in human disease such as psychiatric disorders and cancer. (C) 2015 Wiley Periodicals, Inc.
机译：表观遗传学是对基因表达的遗传变化的研究，这些遗传变化负责发育的调节，并影响几种疾病。但是，了解表观遗传机制的工作原理同样重要。 DNA甲基化是研究最多的表观遗传标记，通常与通过抑制启动子活性和影响基因组稳定性来调节基因表达有关。因此，细胞解释正确的甲基化标记和/或正确的甲基化解释的能力在许多疾病中起作用。结合甲基化DNA的主要蛋白质家族是甲基CpG结合域蛋白或MBD。在这里，我们讨论使这些蛋白质成为一个家族的结构，所有蛋白质家族成员的主要功能和相互作用以及它们在人类疾病（如精神疾病和癌症）中的作用。 （C）2015威利期刊公司

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