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首页> 外文期刊>Journal of cellular biochemistry. >N-Acetyl Cysteine Has Both Gastro-Protective and Anti-Inflammatory Effects in Experimental Rat Models: Its Gastro-Protective Effect Is Related to Its In Vivo and In Vitro Antioxidant Properties
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N-Acetyl Cysteine Has Both Gastro-Protective and Anti-Inflammatory Effects in Experimental Rat Models: Its Gastro-Protective Effect Is Related to Its In Vivo and In Vitro Antioxidant Properties

机译：N-乙酰半胱氨酸在实验性大鼠模型中具有胃保护和抗炎作用：其胃保护作用与其体内和体外抗氧化特性有关

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摘要

N-acetyl cysteine (NAC), a metabolite of sulphur-containing amino acid cysteine, is used as an antioxidant and a mucolytic agent. Therefore, we aimed to investigate anti-inflammatory and anti-ulcerative effects of NAC. We also intended to determine the relation between anti-ulcer effect of NAC and its antioxidant properties by biochemical evaluation. In this study a total of 15 rat groups (n = 6 per group) were used for inflammation and ulcer experiments. Anti-inflammatory effects of NAC have been investigated on six rat groups with carrageenan (CAR)induced paw oedema model. Antiulcer effects of NAC have been investigated on 24 h fasted nine rat groups with IND-induced ulcer model in the presence of positive (LAN, RAN, FAM, and OMEP), negative (untreated IND group) and intact control groups. In biochemical analyses of stomach tissues; glutathione S-transferase (GST), catalase (CAT), myeloperoxidase (MPO), and superoxide dismutase (SOD) enzyme activities and lipid peroxidation (LPO) and the glutathione (GSH) levels were determined. All doses of NAC exerted significant anti-inflammatory effect; even the effect of 900 mg/kg NAC was similar with that of DIC and IND. In gastric tissues NAC administration decreased the level of LPO and activity of CAT, which were increased by IND. Furthermore, NAC increased the GSH level and SOD and GST activities, which decreased in ulcerous stomach tissues. Only MPO activity increased in both IND and NAC groups when compared to healthy rat group. We determined that NAC has both anti-inflammatory and anti-ulcerative effects. (C) 2015 Wiley Periodicals, Inc.
机译：N-乙酰基半胱氨酸（NAC）是含硫氨基酸半胱氨酸的代谢产物，被用作抗氧化剂和粘液溶解剂。因此，我们旨在研究NAC的抗炎和抗溃疡作用。我们还打算通过生化评估确定NAC的抗溃疡作用与其抗氧化性能之间的关系。在这项研究中，总共有15个大鼠组（每组n = 6）用于炎症和溃疡实验。已经用角叉菜胶（CAR）诱导的爪水肿模型研究了六种大鼠NAC的抗炎作用。在有阳性（LAN，RAN，FAM和OMEP），阴性（未治疗的IND组）和完整对照组存在的情况下，已经用IND诱导的溃疡模型对禁食的9只大鼠组在24小时内研究了NAC的抗溃疡作用。在胃组织的生化分析中;确定了谷胱甘肽S-转移酶（GST），过氧化氢酶（CAT），髓过氧化物酶（MPO）和超氧化物歧化酶（SOD）酶的活性以及脂质过氧化（LPO）和谷胱甘肽（GSH）的水平。所有剂量的NAC均具有显着的抗炎作用。即使900 mg / kg NAC的作用也与DIC和IND相似。在胃组织中，NAC的使用降低了LPO的水平和CAT的活性，而IND则增加了这些活性。此外，NAC增加了胃溃疡组织中GSH的水平以及SOD和GST的活性，而这降低了。与健康大鼠组相比，IND和NAC组仅MPO活性增加。我们确定NAC具有抗炎和抗溃疡作用。 （C）2015威利期刊公司

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