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首页> 外文期刊>Journal of cellular biochemistry. >Chlamydia trachomatis Inclusion Disrupts Host Cell Cytokinesis to Enhance Its Growth in Multinuclear Cells
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Chlamydia trachomatis Inclusion Disrupts Host Cell Cytokinesis to Enhance Its Growth in Multinuclear Cells

机译：沙眼衣原体包涵体破坏宿主细胞胞质分裂以增强其在多核细胞中的生长

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摘要

Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, disrupts cytokinesis and causes significant multinucleation in host cells. Here, we demonstrate that multinuclear cells that result from unsuccessful cell division contain significantly higher Golgi content, an important source of lipids for chlamydiae. Using immunofluorescence and fluorescent live cell imaging, we show that C. trachomatis in multinuclear cells indeed intercept Golgi-derived lipid faster than in mononuclear cells. Moreover, multinuclear cells enhance C. trachomatis inclusion growth and infectious particle formation. Together, these results indicate that C. trachomatis robustly position inclusions to the cell equator to disrupt host cell division in order to acquire host Golgi-derived lipids more quickly in multinucleated progeny cells. (C) 2015 Wiley Periodicals, Inc.
机译：沙眼衣原体是细菌性传播感染的主要原因，它会破坏胞质分裂并导致宿主细胞发生明显的多核化。在这里，我们证明了由不成功的细胞分裂引起的多核细胞含有明显更高的高尔基体含量，这是衣原体脂质的重要来源。使用免疫荧光和荧光活细胞成像，我们显示多核细胞中的沙眼衣原体确实比单核细胞更快地拦截了高尔基体来源的脂质。此外，多核细胞可增强沙眼衣原体包涵体的生长和感染性颗粒的形成。总之，这些结果表明，沙眼衣原体牢固地将内含物定位到细胞赤道以破坏宿主细胞分裂，以便在多核后代细胞中更快地获得宿主高尔基体来源的脂质。 （C）2015威利期刊公司

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