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首页> 外文期刊>Journal of cellular biochemistry. >Characterization of Fatty Acid Composition in Bone Marrow Fluid From Postmenopausal Women: Modification After Hip Fracture
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Characterization of Fatty Acid Composition in Bone Marrow Fluid From Postmenopausal Women: Modification After Hip Fracture

机译：绝经后妇女骨髓液中脂肪酸组成的表征：髋部骨折后的修饰

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Bone marrow adipose tissue (BMAT) is associated with low bone mass, although the functional consequences for skeletal maintenance of increased BMAT are currently unclear. BMAT might have a role in systemic energy metabolism, and could be an energy source as well as an endocrine organ for neighboring bone cells, releasing cytokines, adipokines and free fatty acids into the bone marrow microenvironment. The aim of the present report was to compare the fatty acid composition in the bone marrow supernatant fluid (BMSF) and blood plasma of postmenopausal women women (65-80 years old). BMSF was obtained after spinning the aspirated bone marrow samples; donors were classified as control, osteopenic or osteoporotic after dual-energy X-ray absorptiometry. Total lipids from human bone marrow fluid and plasma were extracted, converted to the corresponding methyl esters, and finally analyzed by a gas chromatographer coupled with a mass spectrometer. Results showed that fatty acid composition in BMSF was dynamic and distinct from blood plasma, implying significance in the locally produced lipids. The fatty acid composition in the BMSF was enriched in saturated fatty acid and decreased in unsaturated fatty acids as compared to blood plasma, but this relationship switched in women who suffered a hip fracture. On the other hand, there was no relationship between BMSF and bone mineral density. In conclusion, lipid composition of BMSF is distinct from the circulatory compartment, most likely reflecting the energy needs of the marrow compartment. J. Cell. Biochem. 117: 2370-2376, 2016. (c) 2016 Wiley Periodicals, Inc.
机译：骨髓脂肪组织（BMAT）与低骨量有关，尽管目前尚不清楚增加BMAT的骨骼维持功能的后果。 BMAT可能在全身能量代谢中发挥作用，并且可能是邻近骨细胞的能量来源和内分泌器官，从而将细胞因子，脂肪因子和游离脂肪酸释放到骨髓微环境中。本报告的目的是比较绝经后女性妇女（65-80岁）的骨髓上清液（BMSF）和血浆中的脂肪酸组成。旋转吸出的骨髓样品后获得BMSF。双能X射线吸收测定后，供体被分类为对照，骨质疏松或骨质疏松。从人骨髓液和血浆中提取总脂质，转化为相应的甲酯，最后通过气相色谱仪结合质谱仪进行分析。结果表明，BMSF中的脂肪酸组成是动态的，与血浆不同，这暗示着在局部产生的脂质中的重要性。与血浆相比，BMSF中的脂肪酸成分富含饱和脂肪酸，而不饱和脂肪酸则有所减少，但是这种关系在患有髋部骨折的女性中发生了变化。另一方面，BMSF与骨矿物质密度之间没有关系。总之，BMSF的脂质成分不同于循环系统，最有可能反映了骨髓系统的能量需求。 J.细胞。生化。 117：2370-2376，2016。（c）2016 Wiley Periodicals，Inc.

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