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首页> 外文期刊>Journal of cellular biochemistry. >Nuclear estrogen receptor II (nER-II) is involved in the estrogen-dependent ribonucleoprotein transport in the goat uterus I. Localization of nER-II in snRNP.
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Nuclear estrogen receptor II (nER-II) is involved in the estrogen-dependent ribonucleoprotein transport in the goat uterus I. Localization of nER-II in snRNP.

机译:核雌激素受体II(nER-II)参与山羊子宫I中雌激素依赖性核糖核蛋白的转运。nRER-II在snRNP中的定位。

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摘要

Exposure of goat uterine nuclei to estradiol in vitro results in an immediate exit of ribonucleoproteins (RNP) from the nuclei to the medium. This RNP exit appears to be mediated by an estrogen receptor localized in small nuclear ribonucleoproteins containing U1 and U2 snRNA. Available evidence indicates that the estrogen receptor involved is not the ERalpha, but an alternative form, which is also a 66 kDa protein. This is the nuclear estrogen receptor II (nER-II) that has no DNA-binding capacity. The transport is estrogen-specific since non-estrogenic steroids do not stimulate the transport of the RNP where the receptor is localized.
机译:山羊子宫核在体外暴露于雌二醇会导致核糖核蛋白(RNP)立即从核中释放到培养基中。该RNP出口似乎由位于含有U1和U2 snRNA的小核核糖核蛋白中的雌激素受体介导。现有证据表明,所涉及的雌激素受体不是ERα,而是另一种形式,也是66 kDa蛋白。这是不具有DNA结合能力的核雌激素受体II(nER-II)。转运是雌激素特异性的,因为非雌激素类固醇不会刺激受体所在区域的RNP转运。

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