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首页> 外文期刊>Journal of cellular biochemistry. >Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins.
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Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins.

机译：肿瘤抑制因子HtrA1 / Prss11的细胞内定位及其与HPV16 E6和E7蛋白的关系。

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摘要

We have a long-standing interest in a nuclear protease which appears to be involved in carcinogenesis. We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases. HtrA1 has been classified as a secreted protease involved in TGFbeta signaling, but recent work has shown HtrA1 to be a tumor suppressor. Here we show that processed forms of HtrA1 are found intracellularly and intranuclearly, and the active intranuclear form of HtrA1 shows an approximately Mr 29,000. Further, expression of HPV E6/E7 proteins is associated with a post-transcriptional up-regulation of HtrA1 (most notably the nuclear form), and HtrA1 is found associated with both HPV E6 and E7 proteins.
机译：我们对似乎参与致癌作用的核蛋白酶有着长期的兴趣。我们最近将蛋白酶鉴定为高温需求因子A 1（HtrA1），也称为Prss11，它是蛋白酶的氧化应激反应家族的成员。 HtrA1已被分类为参与TGFbeta信号传导的分泌蛋白酶，但最近的研究表明HtrA1是一种肿瘤抑制因子。在这里，我们显示出HtrA1的加工形式存在于细胞内和核内，而HtrA1的活性核内形式显示出大约29,000先生。此外，HPV E6 / E7蛋白的表达与HtrA1的转录后上调相关（最明显的是核形式），并且发现HtrA1与HPV E6和E7蛋白都相关。

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