...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular biochemistry. >Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils.
【24h】

Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils.

机译：Crk相关底物淋巴细胞型（Cas-L）蛋白在人类嗜中性粒细胞中的表达和酪氨酸磷酸化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Crk-associated substrate lymphocyte type (Cas-L) protein, also known as human enhancer of filamentation 1 (Hef1) or neural precursor cell-expressed, developmentally down-regulated gene 9 (Nedd9), belongs to the Cas family of adapter proteins, which are involved in integrin signaling. Previous reports showed that Cas-L is expressed preferentially in lymphocytes and epithelial cells. Cas-L mediates signals from integrins, T-cell receptors, B-cells receptors, and transforming growth factor beta, leading to cell movement and cell division. Here, we report the expression of Cas-L in neutrophils. Cas-L was tyrosine-phosphorylated when human neutrophils were stimulated by fMLP, tumor necrosis factor-alpha (TNF), or lipopolysaccharide. The tyrosine phosphorylation of Cas-L in fMLP- or TNF- stimulated neutrophils was further enhanced by adhesion of the cells to their substrates. Cas-L was found to be localized at focal adhesions in stimulated neutrophils based on immunofluorescence microscopy. These findings suggest that Cas-L is one of the targets of inflammatory cytokines and is also modulated by cell adhesion process in neutrophils.
机译：Crk相关底物淋巴细胞类型（Cas-L）蛋白，也称为人类丝化1（Hef1）增强子或神经前体细胞表达，发育上调的基因9（Nedd9），属于Cas蛋白衔接子家族，它们参与整联蛋白信号传导。先前的报道表明，Cas-L在淋巴细胞和上皮细胞中优先表达。 Cas-L介导来自整联蛋白，T细胞受体，B细胞受体和转化生长因子β的信号，从而导致细胞运动和细胞分裂。在这里，我们报道中性粒细胞中Cas-L的表达。当fMLP，肿瘤坏死因子-α（TNF）或脂多糖刺激人嗜中性粒细胞时，Cas-L被酪氨酸磷酸化。 fMLP或TNF刺激的嗜中性粒细胞中Cas-L的酪氨酸磷酸化通过细胞粘附至其底物而进一步增强。基于免疫荧光显微镜检查，发现Cas-L位于受刺激的嗜中性粒细胞的粘着斑处。这些发现表明，Cas-L是炎性细胞因子的靶标之一，并且还受嗜中性粒细胞中细胞粘附过程的调节。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号