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首页> 外文期刊>Differentiation: The Journal of the International Society of Differentiation >Lens regeneration in Xenopus is not a mere repeat of lens development, with respect to crystallin gene expression.
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Lens regeneration in Xenopus is not a mere repeat of lens development, with respect to crystallin gene expression.

机译：关于结晶蛋白基因表达，非洲爪蟾的晶状体再生不仅仅是晶状体发育的重复。

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摘要

The spatio-temporal expression of three crystallin genes (alpha A, beta B1 and gamma) in lenses of Xenopus laevis was studied by in situ hybridization to compare the process of lens formation in embryonic development with that of lens regeneration from cornea that occurs in the tadpole. During embryonic lens development, all three crystallin transcripts were initially detected at the same stage of lens placode formation, and subsequently their signals became restricted to the presumptive lens fiber region. At later stages, the three crystallin genes were expressed in primary and secondary lens fibers, but not in lens epithelium. During lens regeneration, alpha A- and beta B1-crystallin signals were first detected in the presumptive lens fiber region of the lens vesicle. The expression of gamma-crystallin, however, appeared later than the other two crystallin genes and was detected only in morphologically discernible lens fibers. In the later stages of lens regeneration, expression of these crystallins was observed only in the lens fiber region, similar to embryonic lens development. These results reveal that lens regeneration from the inner layer of the outer cornea is not simply a repetition of embryonic lens development, when examined at the level of crystallin gene transcription.
机译：通过原位杂交研究了非洲爪蟾晶状体中三个晶体蛋白基因（αA，βB1和γ）的时空表达，以比较晶状体在胚胎发育过程中的形成过程和在角膜中发生的角膜晶状体再生过程。蝌蚪。在胚胎晶状体发育过程中，最初在晶状体斑形成的同一阶段检测到所有三种晶状蛋白转录物，随后它们的信号被限制在假定的晶状体纤维区域。在随后的阶段，这三个晶体蛋白基因在原发性和继发性晶状体纤维中表达，但不在晶状体上皮中表达。在晶状体再生过程中，首先在晶状体囊泡的晶状体纤维区域检测到了αA和βB1晶状体蛋白信号。然而，γ-晶状体蛋白的表达出现晚于其他两个晶状体蛋白基因，并且仅在形态可辨别的晶状体纤维中检测到。在晶状体再生的后期，仅在晶状体纤维区域观察到这些晶状体蛋白的表达，类似于胚胎晶状体的发育。这些结果表明，当从晶状体蛋白基因转录水平检查时，从角膜外层的晶状体再生不仅仅是胚胎晶状体发育的重复。

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