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首页> 外文期刊>Journal of Surgical Oncology >Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma.
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Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma.

机译：E-cadherin，β-catenin，MMP（7和9）和TIMP（1和2）在结直肠癌患者中的预后价值。

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BACKGROUND AND OBJECTIVES: Therapy of colorectal tumors (CRC) based on histology and clinical factors is insufficient to predict the evolution of each patient. The finding of molecular abnormalities able to differentiate subgroups of patients with bad prognosis will improve our ability to treat them successfully. Our purpose was to analyze retrospectively the prognostic input of E-cadherin, beta-catenin, metalloproteinases (MMPs) (7 and 9), and tissue inhibitors of metalloproteinases (TIMPs) (1 and 2) in patients with a follow-up period of 5 years. METHODS: Antigen expression was analyzed by immunohistochemistry. Prognostic evaluation was performed with the multivariate proportional hazards model. RESULTS: We demonstrated a concomitant loss of E-cadherin and beta-catenin at membranous level and an abnormal accumulation of nuclear beta-catenin. Besides, we found that all MMPs and TIMPs studied were overexpressed in CRC tissue. There was no association between the expression of any of these molecules andthe known clinical-pathological parameters employed in CRC pathology. A multivariate analysis demonstrated that the overall survival could be independently predicted by the loss of E-cadherin and the overexpression of TIMP-2. CONCLUSIONS: The expression of E-cadherin and TIMP-2 could be relevant in determining the prognosis of CRC patients and providing a more accurate mechanism for their classification.
机译：背景与目的：基于组织学和临床因素的结直肠肿瘤治疗不足以预测每位患者的进展。发现能够区分预后不良患者亚组的分子异常将改善我们成功治疗它们的能力。我们的目的是回顾性分析E-钙粘蛋白，β-连环蛋白，金属蛋白酶（MMP）（7和9）以及金属蛋白酶组织抑制剂（TIMP）（1和2）在随访期间为5年。方法：采用免疫组织化学方法分析抗原的表达。用多元比例风险模型进行预后评估。结果：我们证明了在膜水平上伴随着E-钙粘蛋白和β-catenin的损失以及核β-catenin的异常积累。此外，我们发现研究的所有MMP和TIMP在CRC组织中均过表达。这些分子中的任何一种的表达与CRC病理学中使用的已知临床病理学参数之间没有关联。多元分析表明，总生存可以通过E-钙粘蛋白的丢失和TIMP-2的过度表达来独立预测。结论：E-cadherin和TIMP-2的表达可能与确定CRC患者的预后有关，并为其分类提供了更准确的机制。

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