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首页> 外文期刊>Journal of Surgical Oncology >Comparison of stage-specific outcome of breast cancer based on 5th and 6th AJCC staging system.
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Comparison of stage-specific outcome of breast cancer based on 5th and 6th AJCC staging system.

机译：比较基于第5和第6 AJCC分期系统的乳腺癌分期结局。

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BACKGROUND AND OBJECTIVES: To investigate the appropriateness of the new staging system (AJCC 6th edition) for breast carcinoma. METHODS: We reviewed the clinicopathologic data of 1,768 breast cancer patients, and their disease stages were re-categorized by the new system. The overall survival (OS) and distant relapse free survival (DRFS) rates were compared between those patients whose stages by the old system (AJCC 5th edition) remained the same (the remainders) and those patients whose stages moved up (the upstaged cases) as well as between the subgroups in the new system. RESULTS: The 10-year DRFS rates of the upstaged cases in each stage were poorer than those of the remainders, and statistical significance was demonstrated for stage IIB and stage IIIA. The 10-year OS rates were also poorer in the upstaged cases, and statistical significance was demonstrated for stage IIIA. Subgroup analysis within the new system between the node-negative versus node-positive subgroups in stages IIA and IIB showeda significant OS difference. The DRFS difference was also shown between the subgroups in stage IIA. CONCLUSIONS: The new staging system seems to more accurately reflect disease outcome, however, a re-evaluation might be required to reflect the impact of nodal involvement upon the new staging system.
机译：背景与目的：探讨新型分期系统（AJCC第6版）对乳腺癌的适用性。方法：我们回顾了1768名乳腺癌患者的临床病理数据，并通过新系统对他们的疾病分期进行了重新分类。比较了按旧系统（AJCC第5版）分期相同（其余）的患者和分期上移的患者（上调病例）的总生存率（OS）和远距离无复发生存率（DRFS）以及新系统中的子组之间。结果：每个阶段的升级病例的10年DRFS率均比其余阶段差，并且在IIB和IIIA期具有统计学意义。在升级后的病例中，十年期OS率也较差，并且在IIIA期具有统计学意义。 IIA和IIB阶段的节点阴性和节点阳性子组之间的新系统内的子组分析显示出显着的OS差异。在IIA期的亚组之间也显示出DRFS差异。结论：新的分期系统似乎可以更准确地反映疾病的结果，但是，可能需要重新评估以反映淋巴结对新分期系统的影响。

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