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首页> 外文期刊>Journal of Surgical Oncology >Clinicopathologic significance of hypoxia-inducible factor 1alpha overexpression in gastric carcinomas.
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Clinicopathologic significance of hypoxia-inducible factor 1alpha overexpression in gastric carcinomas.

机译：缺氧诱导因子1α过表达在胃癌中的临床病理学意义。

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BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a key role in responses to hypoxia and expression of HIF-1alpha downstream genes leads to both an adapted metabolism and increased oxygen supply. We investigated the clinical significance of HIF-1alpha expression in gastric carcinoma. METHODS: We examined HIF-1alpha, vascular endothelial growth factor (VEGF), and insulin-like growth factor-2 (IGF-2) expression patterns immunohistochemically in 126 specimens of gastric carcinoma. CD34 antigen levels were also examined by immunohistochemistry to determine microvessel density (MVD) within tumors and correlations between HIF-1alpha expression, clinicopathological features, and survival were examined. RESULTS: HIF-1alpha expression correlated with tumor size (P<0.005), depth of invasion (P=0.018), VEGF expression (P=0.03), and intra-tumor MVD (P<0.005). IGF-2 expression was more prevalent in HIF-1alpha positive than in HIF-1alpha negative tumors and the 5-year survival rate was 58.4% for HIF-1alpha positive patients and 81.5% for HIF-1alpha negative patients (P=0.009). HIF-1alpha expression is an independent prognostic factor in gastric carcinoma (P=0.032). CONCLUSIONS: Overexpression of HIF-1alpha in gastric carcinomas may upregulate its downstream gene products leading to VEGF-mediated angiogenesis, and resulting in a poor prognosis for patients.
机译：背景：缺氧诱导因子1alpha（HIF-1alpha）在对缺氧的反应中起关键作用，HIF-1alpha下游基因的表达导致代谢适应和供氧增加。我们调查了HIF-1alpha表达在胃癌中的临床意义。方法：我们通过免疫组织化学方法检测了126例胃癌标本中的HIF-1α，血管内皮生长因子（VEGF）和胰岛素样生长因子2（IGF-2）表达模式。还通过免疫组织化学检查了CD34抗原的水平，以确定肿瘤内的微血管密度（MVD），并检查了HIF-1α表达，临床病理特征和生存之间的相关性。结果：HIF-1α的表达与肿瘤大小（P <0.005），浸润深度（P = 0.018），VEGF表达（P = 0.03）和肿瘤内MVD（P <0.005）相关。 HIF-1alpha阳性患者中IGF-2表达比HIF-1alpha阴性患者更为普遍，HIF-1alpha阳性患者的5年生存率是58.4％，HIF-1alpha阴性患者的5年生存率是81.5％（P = 0.009）。 HIF-1alpha表达是胃癌的独立预后因素（P = 0.032）。结论：HIF-1α在胃癌中的过表达可能上调其下游基因产物，从而导致VEGF介导的血管生成，并导致患者预后不良。

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