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首页> 外文期刊>Journal of Surgical Oncology >Preoperative tumor marker doubling time is a useful predictor of recurrence and prognosis after hepatic resection of hepatocellular carcinoma.
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Preoperative tumor marker doubling time is a useful predictor of recurrence and prognosis after hepatic resection of hepatocellular carcinoma.

机译：术前肿瘤标志物加倍时间是肝癌肝切除术后复发和预后的有用预测指标。

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BACKGROUND AND OBJECTIVES: It is important to identify prognostic factors in patients with hepatocellular carcinoma (HCC) before hepatectomy. No previous studies have addressed the predictive efficacy of the preoperative doubling times of alpha-fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA-II). METHODS: A total of 210 HCC patients who underwent a hepatic resection between 1998 and 2006 were prospectively evaluated. Serum AFP and PIVKA-II levels were measured at least twice before surgery to calculate the doubling times. Nineteen clinical factors that can be examined preoperatively, including the doubling times of AFP and PIVKA-II were investigated to identify prognostic factors for disease-free and overall survival after hepatectomy. RESULTS: There was no relationship between preoperative levels and doubling times of AFP and PIVKA-II. In a multivariate analysis, patients with a doubling time of AFP
机译：背景与目的：重要的是在肝切除术之前确定肝细胞癌（HCC）患者的预后因素。先前的研究尚未探讨术前甲胎蛋白（AFP）和维生素K缺乏引起的蛋白（PIVKA-II）加倍的预测疗效。方法：前瞻性评估1998年至2006年间共210例行肝切除术的HCC患者。术前至少两次测量血清AFP和PIVKA-II水平，以计算倍增时间。术前检查了19种临床因素，包括AFP和PIVKA-II的倍增时间，以鉴定肝切除术后无病生存和总体生存的预后因素。结果：术前水平与AFP和PIVKA-II加倍时间之间没有关系。在多变量分析中，AFP

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