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首页> 外文期刊>Journal of Surgical Oncology >Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma.
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Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma.

机译：淋巴结比率是III期黑色素瘤患者重要且独立的预后因素。

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INTRODUCTION: The incidence of melanoma is dramatically increasing worldwide. We hypothesized that the ratio of metastatic to examined lymph node ratio (LNR) would be the most important prognostic factor for stage III patients. METHODS: We retrospectively reviewed our institutional database of melanoma patients and identified 168 patients who underwent lymph node dissection (LND) for stage III disease between 1993 and 2007. Patients were divided into three groups based on LNR (25%, n = 30). Univariate and multivariate analysis was performed using Cox proportional hazards model. RESULTS: The median survival time of the entire group of patients was 34 months. The median number of positive nodes was 2 (range = 1, 55), and the median number of examined nodes was 22 (range = 5-123). Tumor characteristics of the primary melanoma (such as thickness, ulceration, and primary site) were not significant predictors of survival in this analysis. By univariate analysis, LNR was an important prognostic factor. Patients with LNR 10-25% and >25% had decreased survival compared to those patients with LNR 25% predicted survival (HR = 2.5 and 4.0, respectively). CONCLUSION: LNR is an important prognostic factor in patients undergoing LND for stage III melanoma. It can be used to stratify patients being considered for adjuvant therapy trials and should be evaluated using a larger prospective database.
机译：简介：黑色素瘤的发病率在世界范围内急剧增加。我们假设转移与检查淋巴结之比（LNR）的比率将是III期患者最重要的预后因素。方法：我们回顾性研究了我们的黑色素瘤患者的机构数据库，并确定了从1993年至2007年间有168例行III期淋巴结清扫术的患者。根据LNR将患者分为三组（ 25％，n = 30）。使用Cox比例风险模型进行单因素和多因素分析。结果：整组患者的中位生存时间为34个月。阳性节点的中位数为2（范围= 1，55），检查的节点的中位数为22（范围= 5-123）。在该分析中，原发性黑色素瘤的肿瘤特征（例如厚度，溃疡和原发部位）不是生存的重要预测指标。通过单因素分析，LNR是重要的预后因素。与LNR 25％的患者生存率降低（HR =危险比分别为2.0和3.1; P 25％可以预测生存率（HR分别为2.5和4.0）。结论：LNR是接受LND治疗III期黑色素瘤患者的重要预后因素。它可用于对正在考虑进行辅助治疗试验的患者进行分层，并应使用更大的前瞻性数据库进行评估。

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