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首页> 外文期刊>Journal of Surgical Oncology >Systematic Review of Health-Related Quality of Life Issues in Locally Recurrent Rectal Cancer
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Systematic Review of Health-Related Quality of Life Issues in Locally Recurrent Rectal Cancer

机译：对局部复发性直肠癌健康相关生活质量问题的系统评价

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The standardization of surgical techniques supplemented with appropriate neoadjuvant chemoradiation has led to the decline in local recurrence rates of rectal cancer (LRRC) from 25-50% to 5-10%. The outcomes reported for surgical intervention in LRRC is encouraging, however, a number of controversies exist especially in the ultra-advanced and palliative setting. Incorporating health-related quality of life (HRQoL) outcomes in this field could supplement traditional clinical endpoints in assessing the effectiveness of surgical intervention in this cohort. This review aimed to identify the HRQOL themes that might be relevant to patients with LRRC. A systematic review was undertaken to identify all studies reporting HRQoL in LRRC. Each study was evaluated with regards to its design and statistical methodology. A meta-synthesis of qualitative and quantitative studies was undertaken to identify relevant HRQoL themes. A total of 14 studies were identified, with 501 patients, with 80% of patients undergoing surgery. HRQoL was the primary endpoint in eight studies. Eight themes were identified: physical, psychological and social impact, symptoms, financial and occupational impact, relationships with others, communication with healthcare professionals and sexual function. The impact on HRQoL is multifactorial and wide ranging, with a number of issues identified that are not included in current measures. These issues must be incorporated into the assessment of HRQoL in LRRC through the development of a validated, disease-specific tool. J. Surg. Oncol. 2015 111:431-438. (c) 2014 Wiley Periodicals, Inc.
机译：外科手术技术的标准化以及适当的新辅助化学放疗已导致直肠癌（LRRC）的局部复发率从25-50％下降至5-10％。 LRRC的外科手术报道的结果令人鼓舞，但是，尤其是在超前和姑息治疗环境中，存在许多争议。在该领域中纳入与健康相关的生活质量（HRQoL）结果可以补充传统的临床终点，以评估该人群中手术干预的有效性。这项审查旨在确定可能与LRRC患者相关的HRQOL主题。进行了系统的审查，以确定所有LRRC中报告HRQoL的研究。每项研究均对其设计和统计方法进行了评估。进行了定性和定量研究的综合研究，以确定相关的HRQoL主题。共鉴定出14项研究，涉及501例患者，其中80％的患者接受了手术。 HRQoL是八项研究的主要终点。确定了八个主题：身体，心理和社会影响，症状，财务和职业影响，与他人的关系，与医疗保健专业人员的交流以及性功能。对HRQoL的影响是多方面的，影响范围很广，已发现许多当前措施未包括的问题。必须通过开发经过验证的，针对特定疾病的工具，将这些问题纳入LRRC的HRQoL评估中。 J. Surg。 Oncol。 2015 111：431-438。 （c）2014年威利期刊有限公司

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