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首页> 外文期刊>Journal of Surgical Research: Clinical and Laboratory Investigation >Predictive factors for lymph node metastasis in early gastric cancer with signet ring cell histology and their impact on the surgical strategy: Analysis of single institutional experience
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Predictive factors for lymph node metastasis in early gastric cancer with signet ring cell histology and their impact on the surgical strategy: Analysis of single institutional experience

机译：具有印戒细胞组织学的早期胃癌淋巴结转移的预测因素及其对手术策略的影响：单机构经验分析

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Background The prognosis of early gastric cancer (EGC) with signet ring cell histology is more favorable than other undifferentiated gastric adenocarcinomas. An accurate assessment of potential lymph node metastasis is important for the appropriate treatment of EGC with signet ring cell histology. Therefore, this study analyzed the predictive factors associated with lymph node metastasis in patients with this type of EGC. Methods A total of 136 EGC with signet ring cell histology patients who underwent D2 radical gastrectomy were reviewed in this study. The clinicopathologic features were analyzed to identify predictive factors for lymph node metastasis. Results The overall rate of lymph node metastasis in EGC with signet ring cell histology was 10.3%. Using a univariate analysis, the risk factors for lymph node metastasis were identified as the tumor size, depth of tumor invasion, and lymphovascular invasion. The multivariate analysis revealed that tumor size >2 cm, submucosal invasion, and lymphovascular invasion were independent risk factors of lymph node metastasis (P < 0.05). Conclusions The risk of lymph node metastasis of EGC with signet ring cell histology was high in those with tumor sizes ≥2 cm, submucosal tumors, and lymphovascular invasion. A minimally invasive treatment, such as endoscopic resection, might be possible in highly selective cases of EGC with signet ring cell histology with intramucosal invasion, tumor size <2 cm, and no lymphovascular invasion.
机译：背景技术具有印戒细胞组织学特征的早期胃癌（EGC）的预后要优于其他未分化的胃腺癌。准确评估潜在的淋巴结转移对于通过印戒细胞组织学对EGC进行适当治疗非常重要。因此，本研究分析了这类EGC患者与淋巴结转移相关的预测因素。方法回顾性分析了136例行D2根治性胃切除术的EGC并进行了印戒细胞组织学检查的患者。分析临床病理特征，以确定淋巴结转移的预测因素。结果结合印戒细胞组织学检查，EGC淋巴结转移总体率为10.3％。使用单变量分析，将淋巴结转移的危险因素确定为肿瘤大小，肿瘤浸润深度和淋巴管浸润。多元分析表明，肿瘤大小> 2 cm，粘膜下浸润和淋巴管浸润是淋巴结转移的独立危险因素（P <0.05）。结论在肿瘤大小≥2cm，黏膜下肿瘤和淋巴血管浸润的患者中，具有印戒细胞组织学检查的EGC淋巴结转移风险较高。在高度选择性的EGC伴印章环细胞组织学，黏膜内浸润，肿瘤大小<2 cm且无淋巴管浸润的情况下，可能会进行微创治疗，例如内镜切除术。

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