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首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >Expression of type III interferons (IFN lambda s) and their receptor in Sjogren's syndrome
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Expression of type III interferons (IFN lambda s) and their receptor in Sjogren's syndrome

机译：干燥综合征中III型干扰素（IFN lambda s）及其受体的表达

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摘要

Type III interferons (IFNs) or IFN-s (IFN-1/IL29, IFN-2/interleukin (IL)-28A and IFN-3/IL-28B) consist of a recently identified group of IFNs, implicated initially in several human diseases, including cancer and autoimmunity. In this study, we sought to investigate the expression of type III IFNs and their common receptor IFN-R1/IL-28Ra in Sjogren's syndrome (SS). Type III IFN expression was examined in minor salivary gland tissues (MSG), peripheral blood mononuclear cells (PBMCs), sera and resting or Toll-like receptor (TLR)-stimulated salivary gland epithelial cells (SGEC) from SS patients and sicca-complaining controls. All type III IFN family members were detected in ductal and acinar epithelia of MSGs from both SS patients and sicca controls. IFN-2/IL-28A and IFN-3/IL-28B were also expressed in infiltrating mononuclear cells. In SS patients with intermediate MSG lesions, the epithelial expression of IFN-2/IL-28A was more intense compared to sicca controls (P<005). The receptor IFN-R1/IL-28Ra was detected in all types of cells except fibroblasts, and was exceptionally strong in plasmatocytoid dendritic cells, indicating that they are susceptible to type III IFN-mediated regulation. In the periphery, only IFN-1/IL-29 was detected in the sera and was elevated significantly in SS patients with intermediate MSG inflammatory lesions compared to sicca controls (P=00053). None of the type III IFNs was expressed constitutively in resting SGECs; they were all induced readily by TLR-3 stimulation, suggesting that the in-situ epithelial expression can be attributed to local microenvironment. Type III IFNs are expressed in MSGs in a similar pattern to type I IFNs and their expression is probably subjected to micro-environmental regulation, suggesting that they are implicated in the inflammatory processes occurring in the affected exocrine glands.
机译：III型干扰素（IFN）或IFN-s（IFN-1 / IL29，IFN-2 /白介素（IL）-28A和IFN-3 / IL-28B）由最近鉴定出的几组IFN组成，最初与几名人类有关疾病，包括癌症和自身免疫。在这项研究中，我们试图调查Sjogren综合征（SS）中III型IFN及其常见受体IFN-R1 / IL-28Ra的表达。在来自SS患者和干燥期的唾液腺小组织（MSG），外周血单核细胞（PBMC），血清和Toll样受体（TLR）刺激的唾液腺上皮细胞（SGEC）中检测III型IFN表达控件。在SS患者和干燥对照中，在MSG的导管和腺泡上皮中检测到所有III型IFN家族成员。 IFN-2 / IL-28A和IFN-3 / IL-28B也在浸润的单核细胞中表达。在SS患者中，MSG有中度病变，与干燥对照相比，IFN-2 / IL-28A的上皮表达更强（P <0 05）。在除成纤维细胞外的所有类型的细胞中都检测到了IFN-R1 / IL-28Ra受体，并且在浆细胞样树突状细胞中异常强，表明它们对III型IFN介导的调节敏感。在外周，仅血清中检测到IFN-1 / IL-29，并且与干燥中的正常人相比，SS患者中度MSG炎症性病变明显升高（P = 0 0053）。在静止的SGECs中没有III型IFN组成性表达。它们都容易被TLR-3刺激诱导，表明原位上皮表达可以归因于局部微环境。 III型干扰素在MSG中的表达与I型干扰素相似，它们的表达可能受到微环境调节，表明它们与受影响的外分泌腺中发生的炎症过程有关。

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