Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells.

Zunt SL; Burton LV; Goldblatt LI; Dobbins EE; Srinivasan M

首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells.

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Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells.

机译：可溶性形式的Toll样受体4存在于人唾液中，并调节巨噬细胞样细胞对肿瘤坏死因子-α的分泌。

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In health, mucosal inflammation is prevented by tightly regulated responses via Toll-like receptors (TLR) that interact with specific microbe associated molecular patterns. Currently, 13 TLRs have been identified. Based on the specificity of ligand recognition, TLR-2 and TLR-4 can recognize most oral commensal microorganisms. Recent identification of some soluble TLRs (sTLRs) suggests additional regulatory roles for these receptors. We report here the presence of sTLR-4 polypeptides in adult human saliva. Functionally, the salivary sTLR-4 suppressed cytokine secretion by activated macrophages. The sTLR-4 levels were elevated significantly in oral lichen planus (OLP), a chronic inflammatory condition of the oral mucosa characterized by clinical persistence. In contrast, the epithelial cells in the saliva of OLP subjects expressed significantly reduced TLR-2 and TLR-4 mRNA that correlated with fewer bacteria/salivary epithelial cells. Investigating the soluble and cellular components of saliva is useful in identifying potential biomarkers for oral mucosal lesions.

机译：在健康方面，通过与特定微生物相关分子模式相互作用的Toll样受体（TLR）严格调节反应，可以预防粘膜炎症。目前，已经确定了13个TLR。基于配体识别的特异性，TLR-2和TLR-4可以识别大多数口腔共生微生物。最近对一些可溶性TLR（sTLR）的鉴定表明了这些受体的其他调节作用。我们在这里报告了成年人类唾液中sTLR-4多肽的存在。功能上，唾液sTLR-4抑制了活化巨噬细胞分泌的细胞因子。口腔扁平苔藓（OLP）中的sTLR-4水平显着升高，这是一种以临床持续性为特征的口腔粘膜慢性炎症性疾病。相比之下，OLP受试者唾液中的上皮细胞表达的TLR-2和TLR-4 mRNA显着降低，这与较少的细菌/唾液上皮细胞相关。研究唾液的可溶性和细胞成分可用于确定口腔粘膜病变的潜在生物标志物。

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《Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology》 |2009年第2期|共9页
作者
Zunt SL; Burton LV; Goldblatt LI; Dobbins EE; Srinivasan M;
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正文语种 eng
中图分类医学免疫学;
关键词
Saliva; Process of secretion; Human; Toll-like receptor; 唾液;

机译：唾液;分泌过程;人类;Toll样受体;唾液;

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1. Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells. [J] . Zunt SL, Burton LV, Goldblatt LI, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2009,第2期

机译：可溶性形式的Toll样受体4存在于人唾液中，并调节巨噬细胞样细胞对肿瘤坏死因子-α的分泌。
2. Exercise training increases membrane bound form of tumor necrosis factor-alpha receptors with decreases in the secretion of soluble forms of receptors in rat adipocytes. [J] . Ito Y, Ueda H, Kizaki T, Life sciences . 2002,第5期

机译：运动训练增加了大鼠坏死因子-α受体的膜结合形式，同时减少了大鼠脂肪细胞中可溶性形式受体的分泌。
3. Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner. [J] . Boswell S, Sharif S, Alisa A, Immunology: An Official Journal of the British Society for Immunology . 2011,第3期

机译：在CD4 + T细胞上诱导潜伏期相关肽（转化生长因子-β（1））表达以转化生长因子-β依赖的方式降低了Toll样受体4配体诱导的肿瘤坏死因子-α的产生。
4. SECRETION OF MMP-9 BY SOLUBLE GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (SGITR) IS MEDIATED BY PHOSPHOLIPASE D (PLD) IN MURINE MACROPHAGE [C] . Hee-Sook Lee, Hyun-Hee Shin, Hye-Seon Choi Korea-Russia International Symposium on Science and Technology . 2003

机译：通过可溶性糖皮质激素诱导的肿瘤坏死因子受体（Sgitr）分泌MMP-9是由鼠巨噬细胞的磷脂酶D（PLD）介导的介导
5. Butyrate, Bacteriodes thetaiotaomicron and Campylobacter jejuni modulate the expression of beta-defensins, toll-like receptors and cytokines in Caco-2 cells. [D] . Yamashita, Justin W. 2016

机译：丁酸，拟杆菌，空肠弯曲杆菌可调节Caco-2细胞中β-防御素，toll样受体和细胞因子的表达。
6. Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-α secretion by macrophage-like cells [O] . S L Zunt, L V Burton, L I Goldblatt, 2009

机译：可溶性形式的Toll样受体4存在于人唾液中并调节巨噬细胞样细胞的肿瘤坏死因子-α分泌
7. Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-α secretion by macrophage-like cells [O] . Zunt, S L, Burton, L V, Goldblatt, L I, 2009

机译：可溶性形式的Toll样受体4存在于人唾液中，并调节巨噬细胞样细胞的肿瘤坏死因子-α分泌

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Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells.

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