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Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea

机译:韩国济州岛海藻和褐藻的抗凝活性

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摘要

Twenty-two algal species were evaluated for their potential anticoagulant activities. Hot water extracts from selected species, Codium fragile and Sargassum horneri showed high activated partial thromboplastin time (APTT). Ultraflo extract of C fragile and S. horneri exhibited the most potent anticoagulant activity. Furthermore, in both algal species, active compounds were mainly concentrated in > 30 kDa faction. The crude polysaccharide fraction (> 30 kDa; CpoF) of C fragile composed of similar to 80% carbohydrate and similar to 19% of protein; the crude polysaccharide fraction (> 30 kDa; CpoF) of S. horneri was composed of 97% of carbohydrate and similar to 2% of protein. Therefore, most probably the active compound, or compounds of the algal species were related to high molecular weight polysaccharide, or a complex form with carbohydrate and protein (proteoglycan). (c) 2006 Elsevier Ltd. All rights reserved.
机译:评价了22种藻类的潜在抗凝活性。所选物种的脆弱提取物和角藻的热水提取物显示出较高的活化部分凝血活酶时间(APTT)。脆弱的C和霍恩沙门氏菌的Ultraflo提取物表现出最有效的抗凝活性。此外,在两种藻类中,活性化合物主要集中在> 30 kDa的派系中。易碎的C的粗多糖部分(> 30 kDa; CpoF)由约80%的碳水化合物和约19%的蛋白质组成;霍恩氏链球菌的粗多糖级分(> 30 kDa; CpoF)由97%的碳水化合物和接近2%的蛋白质组成。因此,最有可能的是,一种或多种藻类化合物与高分子量多糖或与碳水化合物和蛋白质(蛋白聚糖)的复合物有关。 (c)2006 Elsevier Ltd.保留所有权利。

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