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首页> 外文期刊>Comparative and functional genomics >The Tomato Sequencing Project, the first cornerstone of the International Solanaceae Project (SOL)
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The Tomato Sequencing Project, the first cornerstone of the International Solanaceae Project (SOL)

机译：番茄测序项目，国际茄科计划（SOL）的第一个基石

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摘要

The genome of tomato (Solanum lycopersicum) is being sequenced by an international consortium of 10 countries (Korea, China, the United Kingdom, India, The Netherlands, France, Japan, Spain, Italy and the United States) as part of a larger initiative called the International Solanaceae Genome Project (SOL): Systems Approach to Diversity and Adaptation. The goal of this grassroots initiative, launched in November 2003, is to establish a network of information, resources and scientists to ultimately tackle two of the most significant questions in plant biology and agriculture: (1) How can a common set of genes/proteins give rise to a wide range of morphologically and ecologically distinct organisms that occupy our planet? (2) How can a deeper understanding of the genetic basis of plant diversity be harnessed to better meet the needs of society in an environmentally friendly and sustainable manner? The Solanaceae and closely related species such as coffee, which are included in the scope of the SOL project, are ideally suited to address both of these questions. The first step of the SOL project is to use an ordered BAC approach to generate a high quality sequence for the euchromatic portions of the tomato as a reference for the Solanaceae. Due to the high level of macro and micro-synteny in the Solanaceae the BAC-by-BAC tomato sequence will form the framework for shotgun sequencing of other species. The starting point for sequencing the genome is BACs anchored to the genetic map by overgo hybridization and AFLP technology. The overgos are derived from approximately 1500 markers from the tomato high density F2-2000 genetic map (http://sgn.cornell.edu/). These seed BACs will be used as anchors from which to radiate the tiling path using BAC end sequence data. Annotation will be performed according to SOL project guidelines. All the information generated under the SOL umbrella will be made available in a comprehensive website. The information will be interlinked with the ultimate goal that the comparative biology of the Solanaceae - and beyond - achieves a context that will facilitate a systems biology approach.
机译：作为一项更大计划的一部分，一个由10个国家（韩国，中国，英国，印度，荷兰，法国，日本，西班牙，意大利和美国）组成的国际财团正在对番茄（Solanum lycopersicum）的基因组进行测序。称为国际茄科基因组计划（SOL）：多样性和适应性的系统方法。这项于2003年11月启动的基层计划的目标是建立信息，资源和科学家网络，以最终解决植物生物学和农业中两个最重要的问题：（1）一组常见的基因/蛋白质产生了占据我们星球的多种形态和生态上独特的生物？ （2）如何利用对植物多样性遗传基础的更深刻理解，以环境友好和可持续的方式更好地满足社会的需求？茄科和与之密切相关的物种（例如咖啡）已包含在SOL项目中，非常适合解决这两个问题。 SOL项目的第一步是使用有序BAC方法为番茄的常色部分生成高质量序列，作为茄科的参考。由于茄科中宏观和微观的高度同步，BAC-by-BAC番茄序列将形成shot弹枪测序其他物种的框架。基因组测序的起点是通过过度杂交和AFLP技术将BAC锚定到遗传图谱。过量片段来自番茄高密度F2-2000遗传图谱（http://sgn.cornell.edu/）的约1500个标记。这些种子BAC将用作锚，使用BAC结束序列数据从其辐射出切片路径。注释将根据SOL项目准则进行。 SOL框架下产生的所有信息将在一个综合的网站上提供。这些信息将与茄科的比较生物学及其最终目的的最终目标相互关联，从而达到促进系统生物学方法的目的。

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