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首页> 外文期刊>Comparative and functional genomics >The cadherin superfamily in Anopheles gambiae: a comparative study with Drosophila melanogaster
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The cadherin superfamily in Anopheles gambiae: a comparative study with Drosophila melanogaster

机译：冈比亚按蚊中钙黏着蛋白超家族：与果蝇的比较研究

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摘要

The cadherin superfamily is a diverse and multifunctional group of proteins with extensive representation across genomes of phylogenetically distant species that is involved in cell-cell communication and adhesion. The mosquito Anopheles gambiae is an emerging model organism for the study of innate immunity and host-pathogen interactions, where the malaria parasite induces a profound rearrangement of the actin cytoskeleton at critical stages of infection. We have used bioinformatics tools to retrieve present sequence knowledge about the complete repertoire of cadherins in A. gambiae and compared it to that of the fruit fly, Drosophila melanogaster. In A. gambiae, we have identified 43 genes coding for cadherin extracellular domains that were re-annotated to 38 genes and represent an expansion of this gene family in comparison to other invertebrate organisms. The majority of Drosophila cadherins show a 1 : 1 Anopheles orthologue, but we have observed a remarkable expansion in some groups in A. gambiae, such as N-cadherins, that were recently shown to have a role in the olfactory system of the fruit fly. In vivo dsRNA silencing of overrepresented genes in A. gambiae and other genes showing expression at critical tissues for parasite infection will likely advance our understanding of the problems of host preference and host-pathogen interactions in this mosquito species.
机译：钙粘着蛋白超家族是一种蛋白质的多样化和多功能组，在整个系统发育远缘物种的基因组中具有广泛的代表性，该物种参与细胞间的通讯和粘附。冈比亚按蚊是一种新兴的模式生物，用于研究先天免疫和宿主-病原体相互作用，其中疟原虫在感染的关键阶段诱导肌动蛋白细胞骨架发生深刻的重排。我们已经使用生物信息学工具来检索有关冈比亚拟南芥中钙黏着蛋白完整库的当前序列知识，并将其与果蝇果蝇（Drosophila melanogaster）进行比较。在冈比亚按蚊中，我们已经鉴定了43个编码钙粘蛋白胞外域的基因，这些基因被重新注释为38个基因，与其他无脊椎动物相比，该基因家族的扩展。大多数果蝇钙粘蛋白显示1：1的按蚊直系同源物，但是我们已经观察到冈比亚按蚊的某些群体显着扩展，例如N-钙粘着蛋白，最近它们在果蝇的嗅觉系统中起作用。冈比亚拟南芥中过量表达的基因和其他在寄生虫感染的关键组织中表达的基因的体内dsRNA沉默可能会增进我们对这种蚊子中宿主偏好和宿主-病原体相互作用问题的了解。

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