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Pressures in archaeal protein coding genes: a comparative study

机译：古细菌蛋白质编码基因的压力：一项比较研究

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摘要

Our studies on the bases of codons from 11 completely sequenced archaeal genomes show that, as we move from GC-rich to AT-rich protein-coding gene-containing species, the differences between G and C and between A and T, the purine load (AG content), and also the overall persistence (i.e. the tendency of a base to be followed by the same base) within codons, all increase almost simultaneously, although the extent of increase is different over the three positions within codons. These findings suggest that the deviations from the second parity rule (through the increasing differences between complementary base contents) and the increasing purine load hinder the chance of formation of the intra-strand Watson-Crick base-paired secondary structures in mRNAs (synonymous with the protein-coding genes we dealt with), thereby increasing the translational efficiency. We hypothesize that the AT-rich protein-coding gene-containing archaeal species might have better translational efficiency than their GC-rich counterparts.
机译：我们对来自11个完全测序的古细菌基因组的密码子进行的研究表明，随着我们从富含GC的物种转变为富含AT的蛋白质编码基因物种，G和C之间以及A和T之间的差异，嘌呤负载（AG含量），以及密码子内的总体持久性（即碱基趋于相同碱基的趋势）几乎都同时增加，尽管在密码子内三个位置的增加程度不同。这些发现表明，与第二个奇偶性规则的偏离（通过互补碱基含量之间不断增加的差异）和嘌呤负荷的不断增加，阻碍了在mRNA中形成链内Watson-Crick碱基配对二级结构的机会（与我们处理的蛋白质编码基因），从而提高了翻译效率。我们假设，富含AT的蛋白质编码基因的古细菌物种可能比富含GC的对应物种具有更好的翻译效率。

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