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首页> 外文期刊>Comparative biochemistry and physiology, Part B. Biochemistry & molecular biology >Gene structure of two-domain arginine kinases from Anthopleura japonicus and Pseudocardium sachalinensis
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Gene structure of two-domain arginine kinases from Anthopleura japonicus and Pseudocardium sachalinensis

机译：日本按蚊和拟假单胞菌的两个结构域精氨酸激酶的基因结构

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摘要

Unusual two-domain arginine kinases (AKs) arose independently at least two times during molecular evolution of phosphagen kinases: AKs from the primitive sea anemone Anthapleura japanicas and from the clam Pseudacurdiuni sachalinensis. To elucidate its unusual evolution, the structures of Anthapleura and Pseudocardium AK genes have been determined. The Anthapleura gene consisted of 4 exons and 3 introns: two domains are linked by a bridge intron, and each domain contains one intron in different positions. On the other hand, the Pseudacardiuni gene consisted of 10 exons and 9 introns: two domains are also linked by a bridge intron, and domains 1 and 2 contains 3 and 5 introns, respectively, of which 3 introns are located in exactly same positions. Since the two domains of Pseudacardiurn AK are estimated to have diverged about 290 million years ago, the 3 introns have been conserved at least for this long. Comparison of intron positions in Anthapleura, Pseudocardiwn and C. elegans AK genes indicates that there is no intron conserved through the three AK lineages, in sharp contrast to relatively conservative intron positions in creatine kinase (CK) gene family.
机译：异常的两结构域精氨酸激酶（AKs）在磷酸酶的分子进化过程中至少独立出现了两次：原始海葵Anthapleura japanicas和蛤lam Pseudacurdiuni sachalinensis的AKs。为了阐明其不寻常的进化，已经确定了Anthapleura和伪心AK基因的结构。 Anthapleura基因由4个外显子和3个内含子组成：两个结构域通过桥内含子连接，每个结构域在不同位置包含一个内含子。另一方面，伪心动基因由10个外显子和9个内含子组成：两个结构域也通过桥内含子连接，结构域1和2分别包含3和5个内含子，其中3个内含子位于完全相同的位置。由于估计伪心动蛋白AK的两个结构域在大约2.9亿年前已经分开，所以至少3个内含子已经保存了这么长时间。比较Anthapleura，Pseudocardiwn和C. elegans AK基因中的内含子位置表明，通过这三个AK谱系没有保守的内含子，与肌酸激酶（CK）基因家族中相对保守的内含子位置形成鲜明对比。

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