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首页> 外文期刊>感染症学雑誌 >Two nosocomial outbreaks of sepsis caused by Serratia marcescens, which occurred in July 1999 and January 2002--Tokyo
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Two nosocomial outbreaks of sepsis caused by Serratia marcescens, which occurred in July 1999 and January 2002--Tokyo

机译：1999年7月和2002年1月发生了两次由粘质沙雷氏菌引起的医院败血症暴发-东京

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Two nosocomial outbreaks of sepsis caused by Serratia marcescens, which occurred in Tokyo were the following cases. CASE A: In July 1999, 10 inpatients admitted to the third floor ward of the General Hospital A, developed sudden onset of high fever, coagulation disorders (disseminated intravascular coagulation), and acute renal failure, of which 5 died. Twenty-one strains of Serratia marcescens were isolated from the inpatient's blood and urine, nurse fingers and environmental samples from floor and cooling tower. Serratia infection was strongly suspected as the cause of sepsis. These cases were defined as "inpatients who developed fever 38 degrees C or more during July 26 to 29 and from whom S. marcescens was isolated by blood culture". Ten isolates were detected from the blood. In order to investigate the background of S. marcescens isolation in the hospital and to compare molecular and biochemical characteristics of S. marcescens, cultures were attempted from samples of other inpatients and staffs and hospital environment. Those were classified into 9 groups by various different typings: biotyping with Api Rapid 20; susceptibility typing of antimicrobial agents tested; pulsed-field gel electrophoresis (PFGE) typing of SpeI- or Xba I-restricted chromosome. All 10 isolates causing sepsis were found to be in the same group. CASE B: In January 2002, 24 inpatients, admitted to Neurosurgical Hospital B, developed sudden onset of high fever, of which 7 died. S. marcescens was isolated from a towel, environmental samples and inpatients. These cases were defined as "inpatients who developed fever of 38.5 degrees C and S. marcescens isolated by blood culture". Twelve strains were isolated from the blood samples in 12 cases. In order to investigate the background of S. marcescens isolation in the hospital, cultures were attempted from other inpatient's urine and environmental samples from medical tape, Tshake and a towel. These isolates were classified into 3 groups by the previous typings; biotyping with Api Rapid 20; susceptibility typing of antimicrobial agents tested; and PFGE typing. All 12 isolates in 12 cases were found to be in the same group. These cases of 2 nosocomial outbreaks of sepsis were defined as "in-patient who developed high fever and S. marcescens isolated by blood culture". However in both cases transmission routes of Serratia infection remain unknown by field investigation.
机译：以下是在东京发生的两次由粘质沙雷氏菌引起的败血症的医院内暴发。案例A：1999年7月，有10名住院患者进入综合医院A三楼病房，突然出现高烧，凝血障碍（弥散性血管内凝血）和急性肾衰竭，其中5例死亡。从住院病人的血液和尿液，护士手指以及地板和冷却塔的环境样本中分离出21株粘质沙雷氏菌。强烈怀疑沙雷氏菌感染是败血症的原因。这些病例被定义为“在7月26日至29日期间发烧38摄氏度或更高，并且通过血培养分离出粘菌链霉菌的住院患者”。从血液中检测出十个分离株。为了调查医院中的粘菌链霉菌分离背景，并比较粘菌链霉菌的分子和生化特性，尝试从其他住院病人和医护人员的样本以及医院环境中进行培养。根据不同的类型将它们分为9组：Api Rapid 20进行生物分型;所测试的抗菌剂的敏感性分类; SpeI或Xba I限制性染色体的脉冲场凝胶电泳（PFGE）分型。发现所有引起败血症的10种分离物都在同一组中。病例B：2002年1月，进入神经外科医院B的24名住院病人突然发高烧，其中7人死亡。从毛巾，环境样品和住院病人中分离出粘菌链球菌。将这些病例定义为“通过血液培养分离出38.5℃发烧和marcescens发烧的住院病人”。从血样中分离出十二株。为了调查在医院中分离粘菌链霉菌的背景，尝试从其他住院病人的尿液和医用胶带，Tshake和一条毛巾的环境样本中进行培养。根据以前的分类，将这些菌株分为3组。使用Api Rapid 20进行生物分型;测试的抗菌剂的敏感性类型;和PFGE输入。发现12例中的所有12株分离物都在同一组中。将这2例败血症的医院内暴发病例定义为“通过血液培养分离出发高烧和粘液链球菌的住院患者”。然而，在两种情况下，沙雷氏菌感染的传播途径仍无法通过现场调查得知。

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