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Dosage of inactivated influenza vaccine for infants

机译：婴幼儿灭活流感疫苗的剂量

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BACKGROUND: In Japan, the inoculation dosage of inactivated influenza vaccine for children under 1 year old is 0.1 mL per dose. The dosage is not half as much as that in Europe and the U.S.A. We considered that low efficacy fate of influenza vaccine in children under 1 year old results from its less dosage. So we designed this study to verify this hypothesis. MATERIALS AND METHODS: This study was prospective in design. Subjects were divided into two groups by age: 8 to 11 months old (n = 26) and 12 to 16 months old (n = 22). Infants received 0.1 mL of inactivated influenza vaccine and over 1 year, 0.2 mL. Forty-eight children were inoculated twice at intervals of over 4 weeks. Serum samples were drawn before the first inoculation and 1 month after the second vaccination. Pre- and post-immunization antibody titers were measured. The titers of hemaglutinatinin inhibiting antibodies to the 3 viral strains were assayed. Antibody titers were determined using HAI. RESULTS: The post-vaccination proportions ofchildren with protective HAI antibody titers were significantly smaller in infants than those in children over 1 year old (A/H1N1; 23% vs. 77%, A/H3N2; 39% vs. 73%, B; 0% vs. 32%). The number of children with >four-fold increased antibodies were significantly smaller in infants than that in 1 year old (A/H1N1; 74% vs. 91%, B; 0% vs. 39%). In the mean antibody titer, there were signficant differences between infants and children over 1 year old (A/H1N1; 19 times vs. 56 times, B; 8 times vs. 14 times). CONCLUSION: We consider that significant differences in antibody titers between infants and children over 1 year old were caused by the difference of dosage in influenza vaccines. To obtain protective levels of antibodies by influenza vaccines in infants, they must be inoculated with enough dosage.
机译：背景：在日本，针对1岁以下儿童的灭活流感疫苗的接种剂量为每剂0.1 mL。剂量不是欧洲和美国的一半。我们认为1岁以下儿童流感疫苗的低效命运归因于其剂量较少。因此，我们设计了这项研究以验证这一假设。材料与方法：这项研究是前瞻性的设计。按年龄将受试者分为两组：8至11个月（n = 26）和12至16个月（n = 22）。婴儿接受0.1 mL灭活流感疫苗，超过1年接受0.2 mL。 48名儿童每隔4周以上接种两次。在第一次接种前和第二次接种后1个月抽取血清样品。测量了免疫前和免疫后的抗体滴度。测定了对3种病毒株的血凝素抑制抗体的效价。使用HAI确定抗体滴度。结果：婴儿中具有保护性HAI抗体滴度的儿童的疫苗接种后比例明显低于1岁以上儿童（A / H1N1; 23％比77％，A / H3N2; 39％比73％，B ; 0％与32％）。婴儿中具有> 4倍增加抗体的儿童数量明显小于1岁儿童（A / H1N1; 74％比91％，B; 0％比39％）。在平均抗体滴度中，1岁以上婴幼儿之间存在显着差异（A / H1N1; 19倍对56倍，B; 8倍对14倍）。结论：我们认为，1岁以上婴幼儿抗体滴度的显着差异是由流感疫苗剂量的不同引起的。为了通过婴儿流感疫苗获得保护水平的抗体，必须给它们接种足够的剂量。

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