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首页> 外文期刊>感染症学雑誌 >Antifungal susceptibility of Candida species causing candidemia in Kurume University Hospital and Shaiseikai Hutukaichi Hospital
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Antifungal susceptibility of Candida species causing candidemia in Kurume University Hospital and Shaiseikai Hutukaichi Hospital

机译：久留米大学附属医院和平成会中央医院内引起念珠菌病的念珠菌种类的抗真菌药敏性

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摘要

Prevention of candidemia has been difficult and empirical therapy may eventually reduce morbidity and mortality. Successful empirical therapies depend on understanding of fungal features and antifungal agents. Susceptibility to amphotericin B (AMPH-B), flucytosine (5-FC), fluconazole (FLCZ), itraconazole (ITCZ), miconazole (MCZ), and micafungin (MCFG) of 41 Candida species isolated from blood were determined. Candida albicans was the most common species (23 species), followed by C. parapsilosis (5 species), C. tropicalis (4 species), C. glabrata (3 species), C. guilliermondii (2 species), C. krusei (1 specie), and Candida spp (3 species). The isolation rates of the drug-resistant (DR) fungi were 5% for 5-FC. The rates of DR and susceptible dose dependent (S-DD) fungi were 0% and 2% for FLCZ, respectively. The rates of DR and S-DD fungi were 0% and 17% for ITCZ, respectively. No shift to resistant species in C. albicans occurred in our hospitals. All C. albicans were susceptible for the antifungal agents examined.
机译：预防念珠菌血症一直很困难，经验疗法可能最终会降低发病率和死亡率。成功的经验疗法取决于对真菌特征和抗真菌剂的了解。确定了从血液中分离出的41种念珠菌对两性霉素B（AMPH-B），氟胞嘧啶（5-FC），氟康唑（FLCZ），伊曲康唑（ITCZ），咪康唑（MCZ）和米卡芬净（MCFG）的敏感性。白色念珠菌是最常见的物种（23种），其次是副翼念珠菌（5种），热带念珠菌（4种），glabrata念珠菌（3种），guilliermondii念珠菌（2种），krusei（C。 1种）和念珠菌（3种）。 5-FC的耐药（DR）真菌的分离率为5％。对于FLCZ，DR和敏感剂量依赖性（S-DD）真菌的发生率分别为0％和2％。 ITCZ的DR和S-DD真菌的发生率分别为0％和17％。在我们的医院中，白念珠菌未发生向耐药菌种的转移。所有白色念珠菌均易受检查的抗真菌剂影响。

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