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首页> 外文期刊>感染症学雑誌 >Nosocomial infection caused by multidrug-resistant Staphylococcus aureus with reduced susceptibility to vancomycin and teicoplanin.--Yamagata Prefecture, Japan; May 2004-Jun 2005
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Nosocomial infection caused by multidrug-resistant Staphylococcus aureus with reduced susceptibility to vancomycin and teicoplanin.--Yamagata Prefecture, Japan; May 2004-Jun 2005

机译：多药耐药性金黄色葡萄球菌引起的医院感染，对万古霉素和替考拉宁的敏感性降低。--日本山形县; 2004年5月至2005年6月

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摘要

Nosocomial infection caused by methicillin-resistant Staphylococcus aureus (MRSA) occurred at a major in Yamagata prefecture hospital between May 2004 and June 2005. We studied pulsed-field gel electrophoresis patterns, antimicrobial susceptibility patterns, and bacteriological features, such as coaglase type for eight isolates, including two of methicillin-resistant Staphylococcus epidermidis (MRSE). Our results suggest that this case was caused by a single strain of multidrug-resistant S. aureus. These 8 clinical isolates indicated reduced susceptibility to vancomycin and teicoplanin. PCR assay results for detection of the staphylococcal vanA, vanB, and vanC gene were all negative as all isolates. In transmission electron microscopy, cell walls appeared thicker than those of a susceptible strain from food poisoning. MRSA with reduced susceptibility to glycopeptide antibiotics may not be treated successfully with vancomycin or teicoplanin, making it important to closely observe MRSA with reduced susceptibility to glycopeptide antibiotics.
机译：2004年5月至2005年6月间，在山形县医院的一家大型医院发生了由耐甲氧西林金黄色葡萄球菌（MRSA）引起的医院感染。我们研究了八种脉冲场凝胶电泳图谱，抗菌药物敏感性图谱和细菌学特征，例如共a石型分离株，包括两个耐甲氧西林的表皮葡萄球菌（MRSE）。我们的结果表明，此病例是由单一菌株的多药耐药金黄色葡萄球菌引起的。这8种临床分离株表明对万古霉素和替考拉宁的敏感性降低。由于所有分离株，用于检测葡萄球菌vanA，vanB和vanC基因的PCR测定结果均为阴性。在透射电子显微镜下，细胞壁似乎比食物中毒易感菌株的细胞壁更厚。万古霉素或替考拉宁可能无法成功治疗对糖肽抗生素敏感的MRSA，因此密切观察对糖肽抗生素敏感的MRSA很重要。

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