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首页> 外文期刊>感染症学雑誌 >Two cases of meningitis caused by the same Haemophilus influenzae type B strain in a nursery at a 3-month interval
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Two cases of meningitis caused by the same Haemophilus influenzae type B strain in a nursery at a 3-month interval

机译：间隔3个月的托儿所中由相同的B型流感嗜血杆菌菌株引起的2例脑膜炎

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摘要

We present 2 cases of meningitis caused by the same Haemophilus influenzae type b (Hib) strain in a nursery at a 3-month interval. Causative agents isolated showed good susceptibility to beta-lactams and both patients recovered without any sequelae. Survey culture at each occurrence of meningitis showed 10 asymptomatic nasopharyngeal carriers. Oral rifampin was administrated to all staff and infants, but 2 carriers were found a month later from chemoprophylaxis. Pulsed-field gel electrophoresis analysis showed that the two strains isolated from meningitis patients and 12 from asymptomatic carriers were apparently identical. When systemic Hib infection occurs in a nursery, other infants may be at high risk for secondary disease. It is difficult, however, to eliminate Hib carriage by chemoprophylaxis, indicating that Hib vaccination to prevent systemic Hib infection is necessary in Japan.
机译：我们在托儿所以3个月的间隔介绍2例由相同的B型流感嗜血杆菌（Hib）菌株引起的脑膜炎病例。分离出的病原体对β-内酰胺类表现出良好的敏感性，两名患者均康复，没有任何后遗症。每次发生脑膜炎时的调查文化显示10例无症状的鼻咽携带者。所有工作人员和婴儿均口服了利福平，但化学预防后一个月发现了2个携带者。脉冲场凝胶电泳分析表明，从脑膜炎患者中分离出的两个菌株和从无症状携带者中分离出的两个菌株明显相同。当苗圃发生全身性Hib感染时，其他婴儿可能会继发疾病。但是，很难通过化学预防消除Hib携带，这表明在日本需要接种Hib疫苗以预防全身性Hib感染。

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