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首页> 外文期刊>感染症学雑誌 >Outbreak of acute gastroenteritis caused by human group C rotavirus in a youth educational center in Okayama Prefecture
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Outbreak of acute gastroenteritis caused by human group C rotavirus in a youth educational center in Okayama Prefecture

机译：冈山县青少年教育中心爆发的人类C型轮状病毒引起的急性胃肠炎

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In May 2000, an outbreak of acute gastroenteritis caused by human group C rotavirus (CHRV) occurred in a youth educational center located in the southern area of Okayama Prefecture. A total of 172 schoolchildren and teachers, who consisted of 51 persons belonging to F school and 121 persons belonging to K school, joined in an educational program at the center from May 24 to 26. Eighty-seven individuals (50.6%) of them showed clinical symptoms of gastroenteritis from May 24 to 30, and the outbreak peaked on May 27. The major clinical symptoms were abdominal pain (87.4%), diarrhea (50.6%), nausea or vomiting (21.8%), fever > 37 degrees C (12.6%), and headache (14.9%). The clinical symptoms of the patients in F school were more severe than those in K school. Thirty-two fecal specimens were collected from the patients and examined for gastroenteritis viruses by electron microscopy, ELISA, reverse passive hemagglutination test, and reverse transcription (RT)-PCR. As a result, CHRVs were detected in 21 specimens (65.6%) by RT-PCR. The possible route of the CHRV infection was thought to be a person to person transmission by following reasons: (i), CHRVs were detected in stools from patients who became ill on the first day of the program; (ii), CHRVs were not detected in stools from cooks; (iii), no possible causal food was found by epidemiological analysis of the outbreak. Furthermore, phylogenetic analysis of the VP7 gene among CHRVs isolated in Okayama revealed that the virus detected in this study was more closely related to the virus isolated from a sporadic case of gastroenteritis in 1996 than that isolated from an outbreak occurred in 1999.
机译：2000年5月，在冈山县南部地区的青年教育中心爆发了由人类C型轮状病毒（CHRV）引起的急性胃肠炎暴发。 5月24日至26日，共有172名学童和教师参加了该中心的教育计划，其中包括F学校的51人和K学校的121人。其中有87人（50.6％）参加了该活动胃肠炎的临床症状从5月24日至30日，爆发在5月27日达到高峰。主要临床症状为腹痛（87.4％），腹泻（50.6％），恶心或呕吐（21.8％），发烧> 37摄氏度（ 12.6％）和头痛（14.9％）。 F校的患者的临床症状比K校的更为严重。从患者收集了32份粪便标本，并通过电子显微镜，ELISA，反向被动血凝试验和逆转录（RT）-PCR检查了肠胃炎病毒。结果，通过RT-PCR在21个样本（65.6％）中检测到了CHRV。据认为，CHRV感染的可能途径是人与人之间的传播，其原因如下：（i）在该计划的第一天，病人的粪便中检出了CHRV; （ii）在厨师的粪便中未检测到CHRV; （iii），通过疫情的流行病学分析没有发现可能的病因。此外，对冈山分离出的CHRV中VP7基因的系统发育分析表明，与1999年爆发的肠胃炎相比，1996年从散发性肠胃炎病例中分离出的病毒与本研究中检测到的病毒更紧密相关。

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